TY - JOUR
T1 - Molecular basis of oxidative stress in gouty arthropathy
AU - Zamudio-Cuevas, Yessica
AU - Hernández-Díaz, Cristina
AU - Pineda, Carlos
AU - Reginato, Anthony M.
AU - Cerna-Cortés, Jorge Francisco
AU - Ventura-Ríos, Lucio
AU - López-Reyes, Alberto
N1 - Publisher Copyright:
© 2015, International League of Associations for Rheumatology (ILAR).
PY - 2015/10/26
Y1 - 2015/10/26
N2 - Gout is a disorder of urate metabolism in which persistent high urate levels in the extracellular fluids result in the deposition of monosodium urate (MSU) crystal in joints and periarticular tissues. In recent years, this disease represents an increasingly common health problem, so the pace of investigation in the field has accelerated tremendously. New research advances in the pathogenesis of hyperuricemia and in the understanding of how MSU crystals induce an acute gouty attack have been focused in this review on the processes of inflammation and involvement of the innate immune response; in addition, we discuss new knowledge about the role of the reactive oxygen species in establishing oxidative stress in MSU crystal-induced arthritis.
AB - Gout is a disorder of urate metabolism in which persistent high urate levels in the extracellular fluids result in the deposition of monosodium urate (MSU) crystal in joints and periarticular tissues. In recent years, this disease represents an increasingly common health problem, so the pace of investigation in the field has accelerated tremendously. New research advances in the pathogenesis of hyperuricemia and in the understanding of how MSU crystals induce an acute gouty attack have been focused in this review on the processes of inflammation and involvement of the innate immune response; in addition, we discuss new knowledge about the role of the reactive oxygen species in establishing oxidative stress in MSU crystal-induced arthritis.
KW - Gouty arthropathy
KW - Monosodium urate crystals
KW - Oxidative stress
KW - Synoviocytes
UR - http://www.scopus.com/inward/record.url?scp=84942293973&partnerID=8YFLogxK
U2 - 10.1007/s10067-015-2933-y
DO - 10.1007/s10067-015-2933-y
M3 - Artículo
SN - 0770-3198
VL - 34
SP - 1667
EP - 1672
JO - Clinical Rheumatology
JF - Clinical Rheumatology
IS - 10
ER -