Modulation of tuberculosis-related immune responses by helminths.

Research output: Contribution to journalScientific reviewResearchpeer-review

1 Citation (Scopus)

Abstract

Tuberculosis (TB) continues to be a major worldwide health problem, with 9.4 million newly emerging active tuberculosis cases and causes nearly 2 million deaths annually. Currently, experimental evidence for an strong association between helminths and diminished T helper (Th)1 immunity against Mycobacterium tuberculosis infection is based on studies which show that helminth-induced Th2, T regulatory (Treg) responses and alternatively activated macrophages contribute to enhanced susceptibility to TB. In this context, it has been shown that Th1 response is reduced in helminth coinfected TB patients. This article discusses what is presently known about the types of immune responses modulated by helminths to diminish the protective immune response to TB.
Original languageAmerican English
Pages (from-to)141-144
Number of pages126
JournalJournal of the Egyptian Society of Parasitology
DOIs
StatePublished - 1 Jan 2014

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tuberculosis
Macrophages
Medical problems
Modulation
modulation
macrophages
immunity
infectious diseases
death
health
emerging
magnetic permeability
causes

Cite this

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title = "Modulation of tuberculosis-related immune responses by helminths.",
abstract = "Tuberculosis (TB) continues to be a major worldwide health problem, with 9.4 million newly emerging active tuberculosis cases and causes nearly 2 million deaths annually. Currently, experimental evidence for an strong association between helminths and diminished T helper (Th)1 immunity against Mycobacterium tuberculosis infection is based on studies which show that helminth-induced Th2, T regulatory (Treg) responses and alternatively activated macrophages contribute to enhanced susceptibility to TB. In this context, it has been shown that Th1 response is reduced in helminth coinfected TB patients. This article discusses what is presently known about the types of immune responses modulated by helminths to diminish the protective immune response to TB.",
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Modulation of tuberculosis-related immune responses by helminths. / Méndez-Samperio, P.

In: Journal of the Egyptian Society of Parasitology, 01.01.2014, p. 141-144.

Research output: Contribution to journalScientific reviewResearchpeer-review

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AB - Tuberculosis (TB) continues to be a major worldwide health problem, with 9.4 million newly emerging active tuberculosis cases and causes nearly 2 million deaths annually. Currently, experimental evidence for an strong association between helminths and diminished T helper (Th)1 immunity against Mycobacterium tuberculosis infection is based on studies which show that helminth-induced Th2, T regulatory (Treg) responses and alternatively activated macrophages contribute to enhanced susceptibility to TB. In this context, it has been shown that Th1 response is reduced in helminth coinfected TB patients. This article discusses what is presently known about the types of immune responses modulated by helminths to diminish the protective immune response to TB.

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