Modelo PTZ: Un screening primario para el desarrollo de nuevas moléculas con actividad anticonvulsivante

F. R. Ramos-Morales; J. Correa-Basurto; M. Saavedra-Vélez; M. E. Acosta-Hernández; E. Gasca-Pérez; A. Pérez-Palacios; J. Trujillo-Ferrara

Modelo PTZ: Un screening primario para el desarrollo de nuevas moléculas con actividad anticonvulsivante

Translated title of the contribution: Model PTZ primary screening for the development of new molecules with anticonvulsantactivity

F. R. Ramos-Morales, J. Correa-Basurto, M. Saavedra-Vélez, M. E. Acosta-Hernández, E. Gasca-Pérez, A. Pérez-Palacios, J. Trujillo-Ferrara

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Epilepsy is a chronic disease which is defined by a set of neurological disorders that leaves a high predisposition in the brain to recurrent seizures. While no cure for this brain disorder, however, are used for treatment drugs that inhibit the biochemical mechanisms called anticonvulsants. This make important the need to use animal models to study this disease, as well as, the development and discovery of new drugs, they provide the basics for understanding the mechanisms of disease and are suitable for studying mechanisms of induction of seizures. Within these models stands the model of chemically induced by pentylenetetrazole, which, of its low cost and easy handling is widely used in drug discover y and development of anticonvulsants.

Translated title of the contribution	Model PTZ primary screening for the development of new molecules with anticonvulsantactivity
Original language	Spanish
Pages (from-to)	22-25
Number of pages	4
Journal	Archivos de Neurociencias
Volume	17
Issue number	1
State	Published - Jan 2012

Cite this

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abstract = "Epilepsy is a chronic disease which is defined by a set of neurological disorders that leaves a high predisposition in the brain to recurrent seizures. While no cure for this brain disorder, however, are used for treatment drugs that inhibit the biochemical mechanisms called anticonvulsants. This make important the need to use animal models to study this disease, as well as, the development and discovery of new drugs, they provide the basics for understanding the mechanisms of disease and are suitable for studying mechanisms of induction of seizures. Within these models stands the model of chemically induced by pentylenetetrazole, which, of its low cost and easy handling is widely used in drug discover y and development of anticonvulsants.",

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AU - Ramos-Morales, F. R.

AU - Correa-Basurto, J.

AU - Saavedra-Vélez, M.

AU - Acosta-Hernández, M. E.

AU - Gasca-Pérez, E.

AU - Pérez-Palacios, A.

AU - Trujillo-Ferrara, J.

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AB - Epilepsy is a chronic disease which is defined by a set of neurological disorders that leaves a high predisposition in the brain to recurrent seizures. While no cure for this brain disorder, however, are used for treatment drugs that inhibit the biochemical mechanisms called anticonvulsants. This make important the need to use animal models to study this disease, as well as, the development and discovery of new drugs, they provide the basics for understanding the mechanisms of disease and are suitable for studying mechanisms of induction of seizures. Within these models stands the model of chemically induced by pentylenetetrazole, which, of its low cost and easy handling is widely used in drug discover y and development of anticonvulsants.

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KW - Epilepsy

KW - Pentylenetetrazole

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Modelo PTZ: Un screening primario para el desarrollo de nuevas moléculas con actividad anticonvulsivante

Abstract

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