TY - JOUR
T1 - Microwave-induced organic reaction enhancement (more) chemistry
T2 - Techniques for rapid, safe and inexpensive synthesis
AU - Bose, A. K.
AU - Manhas, M. S.
AU - Banik, B. K.
AU - Robb, E. W.
N1 - Funding Information:
development of improved curricular material involving MORE chemistry for undergraduate and high school laboratory exercises was funded by a grant fro the Howard Hughes Medical Institute in support of our "Chemical Biology Education Enhancement" program. We wish to thank Amy Naqvi and Raza Naqvi for technical assistance.
Funding Information:
Acknowledgement This research was supported in part by Stevens Institute of Technology. The
PY - 1994/1
Y1 - 1994/1
N2 - Synthetic organic reactions have been conducted under microwave irradiation in open vessels in unaltered domestic microwave ovens. Reaction times vary from a few seconds for sub-milligram reactions to about 15 minutes for reactions carried out on a scale of hundreds of grams. Promising results have been obtained for several condensations, as well as the Bischler-Napieralski reaction, the Wolff-Kishner reduction, free radical dehalogenation reactions, and other standard synthetic operations. Rapid catalytic transfer hydrogenation using ammonium formate as the source of hydrogen has been conducted at about 100-130 °C under microwave irradiation. Meaningful, safe and inexpensive synthetic experiments for undergraduate and pre-college students have been developed and tested. The MORE chemistry techniques make it possible to use simple apparatus and very short reaction times. Commercial microwave ovens are now essential equipment in our research and teaching laboratories [1-3]. These ovens are relatively inexpensive, easy to move from one laboratory and set up in another, and safe to operate. Glass, plastics, and ceramics are essentially transparent to microwaves whereas many organic compounds are dipolar in nature and absorb microwave energy readily. We have found that untraditional experimental arrangements are possible for conducting a wide variety of organic reactions in open vessels inside domestic microwave ovens. Depending on the quantity of reactants, most reactions (on a scale of milligrams to several grams) can be completed in minutes instead of hours. One important element of our "Microwave-induced Organic Reaction Enhancement" (MORE) chemistry is the proper choice of a microwave energy transfer agent as the reaction medium.
AB - Synthetic organic reactions have been conducted under microwave irradiation in open vessels in unaltered domestic microwave ovens. Reaction times vary from a few seconds for sub-milligram reactions to about 15 minutes for reactions carried out on a scale of hundreds of grams. Promising results have been obtained for several condensations, as well as the Bischler-Napieralski reaction, the Wolff-Kishner reduction, free radical dehalogenation reactions, and other standard synthetic operations. Rapid catalytic transfer hydrogenation using ammonium formate as the source of hydrogen has been conducted at about 100-130 °C under microwave irradiation. Meaningful, safe and inexpensive synthetic experiments for undergraduate and pre-college students have been developed and tested. The MORE chemistry techniques make it possible to use simple apparatus and very short reaction times. Commercial microwave ovens are now essential equipment in our research and teaching laboratories [1-3]. These ovens are relatively inexpensive, easy to move from one laboratory and set up in another, and safe to operate. Glass, plastics, and ceramics are essentially transparent to microwaves whereas many organic compounds are dipolar in nature and absorb microwave energy readily. We have found that untraditional experimental arrangements are possible for conducting a wide variety of organic reactions in open vessels inside domestic microwave ovens. Depending on the quantity of reactants, most reactions (on a scale of milligrams to several grams) can be completed in minutes instead of hours. One important element of our "Microwave-induced Organic Reaction Enhancement" (MORE) chemistry is the proper choice of a microwave energy transfer agent as the reaction medium.
UR - http://www.scopus.com/inward/record.url?scp=0042924552&partnerID=8YFLogxK
U2 - 10.1163/156856794X00027
DO - 10.1163/156856794X00027
M3 - Artículo
SN - 0922-6168
VL - 20
SP - 1
EP - 11
JO - Research on Chemical Intermediates
JF - Research on Chemical Intermediates
IS - 1
ER -