TY - JOUR
T1 - Microwave Induced Green Synthesis
T2 - Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds
AU - Sahoo, Biswa Mohan
AU - Banik, Bimal Krishna
AU - Ravi Kumar, Bera Venkata Varaha
AU - Panda, Krishna Chandra
AU - Tiwari, Abhishek
AU - Tiwari, Varsha
AU - Singh, Sunil
AU - Kumar, Manish
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023/3
Y1 - 2023/3
N2 - Microwave radiation is used as a heating source during the synthesis of hetero-cyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave heating approach offers a faster rate of reaction, easier work-up procedure, and higher product yield with purity and also reduces environmental pollution. So, microwave heating is applied as a sustainable technology for the efficient production of pyrimidine compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous heterocyclic compound that plays a significant role due to several therapeutic applications. This moiety acts as an essential building block for generating drug candidates with diverse biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil), antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihy-pertensive (minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibac-terial (sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs under microwave irradiation technique and the study of their therapeutic potentials.
AB - Microwave radiation is used as a heating source during the synthesis of hetero-cyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave heating approach offers a faster rate of reaction, easier work-up procedure, and higher product yield with purity and also reduces environmental pollution. So, microwave heating is applied as a sustainable technology for the efficient production of pyrimidine compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous heterocyclic compound that plays a significant role due to several therapeutic applications. This moiety acts as an essential building block for generating drug candidates with diverse biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil), antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihy-pertensive (minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibac-terial (sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs under microwave irradiation technique and the study of their therapeutic potentials.
KW - Bioactivity
KW - development
KW - green synthesis
KW - microwave
KW - pyrimidine
KW - sustainable
UR - http://www.scopus.com/inward/record.url?scp=85147523906&partnerID=8YFLogxK
U2 - 10.2174/0929867329666220622150013
DO - 10.2174/0929867329666220622150013
M3 - Artículo de revisión
C2 - 35733315
AN - SCOPUS:85147523906
SN - 0929-8673
VL - 30
SP - 1029
EP - 1059
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 9
ER -