TY - JOUR
T1 - MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children
AU - Sánchez-Gómez, Ma C.
AU - García-Mejía, K. A.
AU - Pérez-Díaz Conti, M.
AU - Díaz-Rosas, G.
AU - Palma-Lara, I.
AU - Sánchez-Urbina, R.
AU - Klünder-Klünder, M.
AU - Botello-Flores, J. A.
AU - Balderrábano- Saucedo, N. A.
AU - Contreras-Ramos, A.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Complex congenital heart disease (CHD) affects cardiac blood flow, generating a pressure overload in the compromised ventricles and provoking hypertrophy that over time will induce myocardial dysfunction and cause a potential risk of imminent death. Therefore, the early diagnosis of complex CHD is paramount during the first year of life, with surgical treatment of patients favoring survival. In the present study, we analyzed cardiac tissue and plasma of children with cardiac hypertrophy (CH) secondary to CHD for the expression of 11 miRNAs specific to CH in adults. The results were compared with the miRNA expression patterns in tissue and blood of healthy children. In this way, we determined that miRNAs 1, 18b, 21, 23b, 133a, 195, and 208b constitute the expression profile of the cardiac tissue of children with CHD. Meanwhile, miRNAs 21, 23a, 23b, and 24 can be considered specific biomarkers for the diagnosis of CH in infants with CHD. These results suggest that CH secondary to CHD in children differs in its mechanism from that described for adult hypertrophy, offering a new perspective to study the development of this pathology and to determine the potential of hypertrophic miRNAs to be biomarkers for early CH.
AB - Complex congenital heart disease (CHD) affects cardiac blood flow, generating a pressure overload in the compromised ventricles and provoking hypertrophy that over time will induce myocardial dysfunction and cause a potential risk of imminent death. Therefore, the early diagnosis of complex CHD is paramount during the first year of life, with surgical treatment of patients favoring survival. In the present study, we analyzed cardiac tissue and plasma of children with cardiac hypertrophy (CH) secondary to CHD for the expression of 11 miRNAs specific to CH in adults. The results were compared with the miRNA expression patterns in tissue and blood of healthy children. In this way, we determined that miRNAs 1, 18b, 21, 23b, 133a, 195, and 208b constitute the expression profile of the cardiac tissue of children with CHD. Meanwhile, miRNAs 21, 23a, 23b, and 24 can be considered specific biomarkers for the diagnosis of CH in infants with CHD. These results suggest that CH secondary to CHD in children differs in its mechanism from that described for adult hypertrophy, offering a new perspective to study the development of this pathology and to determine the potential of hypertrophic miRNAs to be biomarkers for early CH.
KW - Cardiac hypertrophy
KW - Children
KW - Complex congenital heart
KW - MicroRNAs
UR - http://www.scopus.com/inward/record.url?scp=85017150509&partnerID=8YFLogxK
U2 - 10.1007/s00246-017-1607-8
DO - 10.1007/s00246-017-1607-8
M3 - Artículo
SN - 0172-0643
VL - 38
SP - 991
EP - 1003
JO - Pediatric Cardiology
JF - Pediatric Cardiology
IS - 5
ER -