Microencapsulación de tramadol en ácido poliláctico mediante secado por aspersión

Orestes Darío López Hernández; Martha Gómez Carril; Alejandro Saúl Padrón Yaquis; Arturo Toledo Rivero; Carlos Alfredo Toledo Sanchez; Enma Reyes Sanchez; Edilso Reguera Ruiz; Julio Duque Rodríguez; Bertha López Pelaez

Microencapsulación de tramadol en ácido poliláctico mediante secado por aspersión

Translated title of the contribution: Microencapsulation of Tramadol in polyactic acid by aspersion drying

Orestes Darío López Hernández, Martha Gómez Carril, Alejandro Saúl Padrón Yaquis, Arturo Toledo Rivero, Carlos Alfredo Toledo Sanchez, Enma Reyes Sanchez, Edilso Reguera Ruiz, Julio Duque Rodríguez, Bertha López Pelaez

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An interesting subject for pharmaceutical industry is the search of technologies to achieve pharmaceutical ways for administration and transportation of cytostatics, anti-inflammatories, peptides and hormones among other drugs implicating a reduction of its toxicity or a contolled releasing of active principle to increase its effectiveness. In present paper authors studied the influence of fluid flow in feeding, of atomization air and of driying; different physicochemical and morphological features (size, shape, porosity and distribution in the particles size, and the effectiveness of active principle encapsulation) of Tramadol's microspheres. As result, it was possible to achieve microspheres of 18.93 ± 2.31 :m with an spherical shape, a non-porous surface demostrating it by X-ray difractometry and Tramadol encapsulation in the polymer.

Translated title of the contribution	Microencapsulation of Tramadol in polyactic acid by aspersion drying
Original language	Spanish
Pages (from-to)	432-442
Number of pages	11
Journal	Revista Cubana de Farmacia
Volume	44
Issue number	4
State	Published - Oct 2010
Externally published	Yes

Cite this

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title = "Microencapsulaci{\'o}n de tramadol en {\'a}cido polil{\'a}ctico mediante secado por aspersi{\'o}n",

abstract = "An interesting subject for pharmaceutical industry is the search of technologies to achieve pharmaceutical ways for administration and transportation of cytostatics, anti-inflammatories, peptides and hormones among other drugs implicating a reduction of its toxicity or a contolled releasing of active principle to increase its effectiveness. In present paper authors studied the influence of fluid flow in feeding, of atomization air and of driying; different physicochemical and morphological features (size, shape, porosity and distribution in the particles size, and the effectiveness of active principle encapsulation) of Tramadol's microspheres. As result, it was possible to achieve microspheres of 18.93 ± 2.31 :m with an spherical shape, a non-porous surface demostrating it by X-ray difractometry and Tramadol encapsulation in the polymer.",

keywords = "Aspersion driying, Microencapsulation, Tramadol",

author = "Hern{\'a}ndez, {Orestes Dar{\'i}o L{\'o}pez} and Carril, {Martha G{\'o}mez} and Yaquis, {Alejandro Sa{\'u}l Padr{\'o}n} and Rivero, {Arturo Toledo} and Sanchez, {Carlos Alfredo Toledo} and Sanchez, {Enma Reyes} and Ruiz, {Edilso Reguera} and Rodr{\'i}guez, {Julio Duque} and Pelaez, {Bertha L{\'o}pez}",

year = "2010",

month = oct,

language = "Espa{\~n}ol",

volume = "44",

pages = "432--442",

journal = "Revista Cubana de Farmacia",

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T1 - Microencapsulación de tramadol en ácido poliláctico mediante secado por aspersión

AU - Hernández, Orestes Darío López

AU - Carril, Martha Gómez

AU - Yaquis, Alejandro Saúl Padrón

AU - Rivero, Arturo Toledo

AU - Sanchez, Carlos Alfredo Toledo

AU - Sanchez, Enma Reyes

AU - Ruiz, Edilso Reguera

AU - Rodríguez, Julio Duque

AU - Pelaez, Bertha López

PY - 2010/10

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N2 - An interesting subject for pharmaceutical industry is the search of technologies to achieve pharmaceutical ways for administration and transportation of cytostatics, anti-inflammatories, peptides and hormones among other drugs implicating a reduction of its toxicity or a contolled releasing of active principle to increase its effectiveness. In present paper authors studied the influence of fluid flow in feeding, of atomization air and of driying; different physicochemical and morphological features (size, shape, porosity and distribution in the particles size, and the effectiveness of active principle encapsulation) of Tramadol's microspheres. As result, it was possible to achieve microspheres of 18.93 ± 2.31 :m with an spherical shape, a non-porous surface demostrating it by X-ray difractometry and Tramadol encapsulation in the polymer.

AB - An interesting subject for pharmaceutical industry is the search of technologies to achieve pharmaceutical ways for administration and transportation of cytostatics, anti-inflammatories, peptides and hormones among other drugs implicating a reduction of its toxicity or a contolled releasing of active principle to increase its effectiveness. In present paper authors studied the influence of fluid flow in feeding, of atomization air and of driying; different physicochemical and morphological features (size, shape, porosity and distribution in the particles size, and the effectiveness of active principle encapsulation) of Tramadol's microspheres. As result, it was possible to achieve microspheres of 18.93 ± 2.31 :m with an spherical shape, a non-porous surface demostrating it by X-ray difractometry and Tramadol encapsulation in the polymer.

KW - Aspersion driying

KW - Microencapsulation

KW - Tramadol

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M3 - Artículo

SN - 0034-7515

VL - 44

SP - 432

EP - 442

JO - Revista Cubana de Farmacia

JF - Revista Cubana de Farmacia

IS - 4

ER -

Microencapsulación de tramadol en ácido poliláctico mediante secado por aspersión

Abstract

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