TY - CHAP
T1 - Metabolomics and fluxomics studies in the medicinal plant Catharanthus roseus
AU - Barrales-Cureño, Hebert Jair
AU - Montiel-Montoya, Jorge
AU - Espinoza-Pérez, José
AU - Cortez-Ruiz, Juan Antonio
AU - Lucho-Constantino, Gonzalo Guillermo
AU - Zaragoza-Martínez, Fabiola
AU - Salazar-Magallón, Jesús Antonio
AU - Reyes, César
AU - Lorenzo-Laureano, José
AU - López-Valdez, Luis Germán
N1 - Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Various applications of omics sciences in the study of medicinal plants have been noticed in pharmacology field, specifically in drug discovery, treatment, and dose assessment. In metabolic engineering, the omics sciences support has been used in multicomplex analysis. Catharanthus roseus synthesize terpenoid indole alkaloids through a complex network, therefore it is becoming an excellent biological model in order to analyze metabolomics and fluxomics during alkaloid metabolism of this medicinally valuable plant. C. roseus plays a key role in the traditional medicine, which has been used to treat several diseases, as it contains alkaloids with antileukemic, sedative and antihypertensive properties. Therefore, the main purpose of this chapter is to discuss the spectrum of metabolomics and fluxomics studies performed in C. roseus, from the point of view of studies carried out directly in plants and in vitro culture as well as in the elicitation processes in suspended cells of C. roseus and the metabolic changes generated by the elicitation.
AB - Various applications of omics sciences in the study of medicinal plants have been noticed in pharmacology field, specifically in drug discovery, treatment, and dose assessment. In metabolic engineering, the omics sciences support has been used in multicomplex analysis. Catharanthus roseus synthesize terpenoid indole alkaloids through a complex network, therefore it is becoming an excellent biological model in order to analyze metabolomics and fluxomics during alkaloid metabolism of this medicinally valuable plant. C. roseus plays a key role in the traditional medicine, which has been used to treat several diseases, as it contains alkaloids with antileukemic, sedative and antihypertensive properties. Therefore, the main purpose of this chapter is to discuss the spectrum of metabolomics and fluxomics studies performed in C. roseus, from the point of view of studies carried out directly in plants and in vitro culture as well as in the elicitation processes in suspended cells of C. roseus and the metabolic changes generated by the elicitation.
KW - elicitation
KW - fluxomics
KW - metabolomics
KW - plant cell culture
KW - terpenoid indole alkaloids.
UR - http://www.scopus.com/inward/record.url?scp=85100713543&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-819590-1.00003-3
DO - 10.1016/B978-0-12-819590-1.00003-3
M3 - Capítulo
AN - SCOPUS:85100713543
SN - 9780128227756
SP - 61
EP - 86
BT - Medicinal and Aromatic Plants
PB - Elsevier
ER -