TY - JOUR
T1 - Metabolic engineering of microorganisms for the production of multifunctional non-protein amino acids
T2 - γ-aminobutyric acid and δ-aminolevulinic acid
AU - Su, Anping
AU - Yu, Qijun
AU - Luo, Ying
AU - Yang, Jinshui
AU - Wang, Entao
AU - Yuan, Hongli
N1 - Publisher Copyright:
© 2021 The Authors. Microbial Biotechnology published by Society for Applied Microbiology and John Wiley & Sons Ltd and Society for Applied Microbiology.
PY - 2021/11
Y1 - 2021/11
N2 - Gamma-aminobutyric acid (GABA) and delta-aminolevulinic acid (ALA), playing important roles in agriculture, medicine and other fields, are multifunctional non-protein amino acids with similar and comparable properties and biosynthesis pathways. Recently, microbial synthesis has become an inevitable trend to produce GABA and ALA due to its green and sustainable characteristics. In addition, the development of metabolic engineering and synthetic biology has continuously accelerated and increased the GABA and ALA yield in microorganisms. Here, focusing on the current trends in metabolic engineering strategies for microbial synthesis of GABA and ALA, we analysed and compared the efficiency of various metabolic strategies in detail. Moreover, we provide the insights to meet challenges of realizing industrially competitive strains and highlight the future perspectives of GABA and ALA production.
AB - Gamma-aminobutyric acid (GABA) and delta-aminolevulinic acid (ALA), playing important roles in agriculture, medicine and other fields, are multifunctional non-protein amino acids with similar and comparable properties and biosynthesis pathways. Recently, microbial synthesis has become an inevitable trend to produce GABA and ALA due to its green and sustainable characteristics. In addition, the development of metabolic engineering and synthetic biology has continuously accelerated and increased the GABA and ALA yield in microorganisms. Here, focusing on the current trends in metabolic engineering strategies for microbial synthesis of GABA and ALA, we analysed and compared the efficiency of various metabolic strategies in detail. Moreover, we provide the insights to meet challenges of realizing industrially competitive strains and highlight the future perspectives of GABA and ALA production.
UR - http://www.scopus.com/inward/record.url?scp=85102054254&partnerID=8YFLogxK
U2 - 10.1111/1751-7915.13783
DO - 10.1111/1751-7915.13783
M3 - Artículo de revisión
C2 - 33675575
AN - SCOPUS:85102054254
SN - 1751-7907
VL - 14
SP - 2279
EP - 2290
JO - Microbial Biotechnology
JF - Microbial Biotechnology
IS - 6
ER -