TY - JOUR
T1 - Medicina regenerativa para Álceras crónicas
T2 - Aplicación cutánea de células troncales mesenquimales de Gelatina de Wharton
AU - Parra-Barrera, A.
AU - Mejía-Barradas, C. M.
AU - Calzada-Mendoza, C. C.
AU - Mera-Jiménez, E.
AU - Sánchez-Corrales, A. L.
AU - Gutiérrez-Iglesias, G.
N1 - Publisher Copyright:
© 2019 Sociedad Mexicana de Ingenieria Biomedica. All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Use of mesenchymal cells has emerged as an important part in regenerative medicine with positive effects in the recovery of damaged or lost tissues. Chronic ulcers include skin lesions that affect a large part of the population with diabetes mellitus, (for example, 9.14 develop diabetic foot according to ENSANUT 2016) and represent considerable economic expenses, due to poor quality of life in patients. The conventional treatment that is carried out in these cases is long term, and the generated beneficial effects that are presented are limited, since the injuries recur due to not having a specific and regenerative treatment, only palliative. That is why in this work they were obtained and used mesenchymal stem cells derived from Wharton's jelly (MSC-WJ) under the criteria proposed by the International Society for Cell Therapy. The treatment was applied in two patients with chronic ulcers phlebostatic of different medical conditions and short-term monitoring, so it was a limited study. The results showed that MSC-WJ induced skin reconstruction by tissue formation granulation, in addition to decreasing the chronic inflammatory process in the area of damage, which favored the index of wound healing. Therefore, the use of MSC-WJ in chronic phlebostatic ulcers is proposed as a treatment in the regeneration of the tissue structure with short-term results.
AB - Use of mesenchymal cells has emerged as an important part in regenerative medicine with positive effects in the recovery of damaged or lost tissues. Chronic ulcers include skin lesions that affect a large part of the population with diabetes mellitus, (for example, 9.14 develop diabetic foot according to ENSANUT 2016) and represent considerable economic expenses, due to poor quality of life in patients. The conventional treatment that is carried out in these cases is long term, and the generated beneficial effects that are presented are limited, since the injuries recur due to not having a specific and regenerative treatment, only palliative. That is why in this work they were obtained and used mesenchymal stem cells derived from Wharton's jelly (MSC-WJ) under the criteria proposed by the International Society for Cell Therapy. The treatment was applied in two patients with chronic ulcers phlebostatic of different medical conditions and short-term monitoring, so it was a limited study. The results showed that MSC-WJ induced skin reconstruction by tissue formation granulation, in addition to decreasing the chronic inflammatory process in the area of damage, which favored the index of wound healing. Therefore, the use of MSC-WJ in chronic phlebostatic ulcers is proposed as a treatment in the regeneration of the tissue structure with short-term results.
KW - Chronic ulcers
KW - Mesenchymal stem cells
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85086657952&partnerID=8YFLogxK
U2 - 10.17488/RMIB.40.2.1
DO - 10.17488/RMIB.40.2.1
M3 - Artículo
SN - 0188-9532
VL - 40
JO - Revista Mexicana de Ingenieria Biomedica
JF - Revista Mexicana de Ingenieria Biomedica
IS - 2
M1 - e201832
ER -