TY - JOUR
T1 - Mechanochemistry
T2 - A green approach in the preparation of pharmaceutical cocrystals
AU - Solares-Briones, Mizraín
AU - Coyote-Dotor, Guadalupe
AU - Páez-Franco, José C.
AU - Zermeño-Ortega, Miriam R.
AU - Contreras, Carmen Myriam de la O.
AU - Canseco-González, Daniel
AU - Avila-Sorrosa, Alcives
AU - Morales-Morales, David
AU - Germán-Acacio, Juan M.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6
Y1 - 2021/6
N2 - Mechanochemistry is considered an alternative attractive greener approach to prepare diverse molecular compounds and has become an important synthetic tool in different fields (e.g., physics, chemistry, and material science) since is considered an ecofriendly procedure that can be carried out under solvent free conditions or in the presence of minimal quantities of solvent (catalytic amounts). Being able to substitute, in many cases, classical solution reactions often requiring signifi-cant amounts of solvents. These sustainable methods have had an enormous impact on a great variety of chemistry fields, including catalysis, organic synthesis, metal complexes formation, preparation of multicomponent pharmaceutical solid forms, etc. In this sense, we are interested in highlighting the advantages of mechanochemical methods on the obtaining of pharmaceutical cocrystals. Hence, in this review, we describe and discuss the relevance of mechanochemical procedures in the formation of multicomponent solid forms focusing on pharmaceutical cocrystals. Additionally, at the end of this paper, we collect a chronological survey of the most representative scientific papers reporting the mechanochemical synthesis of cocrystals.
AB - Mechanochemistry is considered an alternative attractive greener approach to prepare diverse molecular compounds and has become an important synthetic tool in different fields (e.g., physics, chemistry, and material science) since is considered an ecofriendly procedure that can be carried out under solvent free conditions or in the presence of minimal quantities of solvent (catalytic amounts). Being able to substitute, in many cases, classical solution reactions often requiring signifi-cant amounts of solvents. These sustainable methods have had an enormous impact on a great variety of chemistry fields, including catalysis, organic synthesis, metal complexes formation, preparation of multicomponent pharmaceutical solid forms, etc. In this sense, we are interested in highlighting the advantages of mechanochemical methods on the obtaining of pharmaceutical cocrystals. Hence, in this review, we describe and discuss the relevance of mechanochemical procedures in the formation of multicomponent solid forms focusing on pharmaceutical cocrystals. Additionally, at the end of this paper, we collect a chronological survey of the most representative scientific papers reporting the mechanochemical synthesis of cocrystals.
KW - Green reactions
KW - Mechanochemistry
KW - Pharmaceutical cocrystals
UR - http://www.scopus.com/inward/record.url?scp=85107732515&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics13060790
DO - 10.3390/pharmaceutics13060790
M3 - Artículo
C2 - 34070646
AN - SCOPUS:85107732515
SN - 1999-4923
VL - 13
JO - Pharmaceutics
JF - Pharmaceutics
IS - 6
M1 - 790
ER -