TY - JOUR
T1 - Los genes del cáncer
AU - Peralta-Rodríguez, Raúl
AU - Valdivia, Alejandra
AU - Mendoza, Mónica
AU - Rodríguez, Jade
AU - Marrero, Daniel
AU - Paniagua, Lucero
AU - Romero, Pablo
AU - Taniguchi, Keiko
AU - Salcedo, Mauricio
PY - 2015
Y1 - 2015
N2 - In 2010, in a cancer genes census, 291 genes were enumerated. These represent near to the 1 % of the total genes, for which there is enough biological evidence that they belong to a new genes classification, known as the cancer genes. These have been defined as the causal genes for sporadic or familiar cancer, when they mutate. The mutation types for these genes includes amplifications, point mutations, deletions, genomic rearranges, amongst others, which lead to a protein over-expression, muting, production of chimeric proteins or a de novo expression. In conjunction these genomic alterations or those of the genetic expression, when they affect specific genes which contribute to the development of cancer, are denominated as cancer genes. It is possible that the list of these alterations will grow longer due to new strategies being developed, for example, the genomic analysis.
AB - In 2010, in a cancer genes census, 291 genes were enumerated. These represent near to the 1 % of the total genes, for which there is enough biological evidence that they belong to a new genes classification, known as the cancer genes. These have been defined as the causal genes for sporadic or familiar cancer, when they mutate. The mutation types for these genes includes amplifications, point mutations, deletions, genomic rearranges, amongst others, which lead to a protein over-expression, muting, production of chimeric proteins or a de novo expression. In conjunction these genomic alterations or those of the genetic expression, when they affect specific genes which contribute to the development of cancer, are denominated as cancer genes. It is possible that the list of these alterations will grow longer due to new strategies being developed, for example, the genomic analysis.
KW - CRBP1
KW - Genes
KW - HER2/neu
KW - Mutation
UR - http://www.scopus.com/inward/record.url?scp=85021851649&partnerID=8YFLogxK
M3 - Artículo de revisión
C2 - 26462514
AN - SCOPUS:85021851649
SN - 0443-5117
VL - 53
SP - S178-S187
JO - Revista Medica del Instituto Mexicano del Seguro Social
JF - Revista Medica del Instituto Mexicano del Seguro Social
ER -