TY - JOUR
T1 - Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants
AU - Estrada-Camarena, Erika
AU - López-Rubalcava, Carolina
AU - Hernández-Aragón, Azucena
AU - Mejía-Mauries, Silvia
AU - Picazo, Ofir
N1 - Funding Information:
The present study was supported by Consejo Nacional de Ciencia y Tecnología (EE-C grant number 104659), Instituto Nacional de Psiquiatría (EE-C grant number 189) and SIP-IPN and COFAA (OP). Acknowledgments
PY - 2011/10
Y1 - 2011/10
N2 - Controversial results related to effectiveness of estrogen replacement therapy (ERT) to alleviate depression are frequently reported. The discrepancies could be related to (a) time when ERT is initiated after the beginning of menopause and/or (b) type of estrogen used. Furthermore, estrogens modulate the antidepressant effect of different compounds; therefore, the effectiveness of antidepressant drugs could also depend on the menopausal status. The aim of the present study was to analyze whether the time after estrogen decline can influence antidepressant-like effects of two estrogens and/or two antidepressants. Thus, the antidepressant-like actions of 17β-estradiol (E2), 17α-ethynyl-estradiol (EE2), fluoxetine (FLX) and desipramine (DMI) were studied at different periods (1, 3 and 12 weeks) after ovariectomy (OVX), using the forced swimming test (FST). Results showed that OVX increased depressive-like behavior only 1 week after OVX. The antidepressant-like actions of E2, but not those of EE2, were cancelled 12 weeks after OVX. Conversely, antidepressant-like actions of FLX and DMI were observed at 1, 3 and 12 weeks after OVX. In conclusion, while the antidepressant-like effects of estrogens depended on the time at which treatment is initiated after OVX as well as on the estrogenic compound used, antidepressant-like effects of FLX and DMI were not blocked by OVX.
AB - Controversial results related to effectiveness of estrogen replacement therapy (ERT) to alleviate depression are frequently reported. The discrepancies could be related to (a) time when ERT is initiated after the beginning of menopause and/or (b) type of estrogen used. Furthermore, estrogens modulate the antidepressant effect of different compounds; therefore, the effectiveness of antidepressant drugs could also depend on the menopausal status. The aim of the present study was to analyze whether the time after estrogen decline can influence antidepressant-like effects of two estrogens and/or two antidepressants. Thus, the antidepressant-like actions of 17β-estradiol (E2), 17α-ethynyl-estradiol (EE2), fluoxetine (FLX) and desipramine (DMI) were studied at different periods (1, 3 and 12 weeks) after ovariectomy (OVX), using the forced swimming test (FST). Results showed that OVX increased depressive-like behavior only 1 week after OVX. The antidepressant-like actions of E2, but not those of EE2, were cancelled 12 weeks after OVX. Conversely, antidepressant-like actions of FLX and DMI were observed at 1, 3 and 12 weeks after OVX. In conclusion, while the antidepressant-like effects of estrogens depended on the time at which treatment is initiated after OVX as well as on the estrogenic compound used, antidepressant-like effects of FLX and DMI were not blocked by OVX.
KW - 17α-ethynyl-estradiol
KW - 17β-estradiol
KW - antidepressant-like effect
KW - desipramine
KW - fluoxetine
KW - forced swimming test
KW - long-term ovariectomy
UR - http://www.scopus.com/inward/record.url?scp=79959985227&partnerID=8YFLogxK
U2 - 10.1177/0269881111408456
DO - 10.1177/0269881111408456
M3 - Artículo
C2 - 21890587
SN - 0269-8811
VL - 25
SP - 1365
EP - 1377
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
IS - 10
ER -