Laser diode system for interstitial photodynamic therapy

L. Pacheco; S. Stolik; J. De La Rosa; A. De La Cadena

doi:10.1109/TLA.2014.6868857

Laser diode system for interstitial photodynamic therapy

L. Pacheco, S. Stolik, J. De La Rosa, A. De La Cadena

Escuela Superior de Ingeniería Mecánica y Eléctrica (ESIME), Unidad Zacatenco

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Interstitial Photodynamic Therapy (IPDT) is a promising form of treatment of deep-seated and bulky malignant tumors, based on the lethal cell response to the photochemical reactions when drug is light activated at presence of oxygen. After intravenous administration, the drug is retained selectively by malignant cells, and then, the light is delivered to the target tissue through multiple optical fibers. In order to accomplish an effective internal illumination, laser sources are preferably used because of two important reasons: the laser beam is easily focused to optical fibers, and the monochromatic light can be confined to the narrow absorption band of the drug. In this work we present the design of an irradiation laser system, which involves a 635nm laser diode and a delivering fiber system, for 5-ALA mediated IPDT

Original language	English
Article number	6868857
Pages (from-to)	574-579
Number of pages	6
Journal	IEEE Latin America Transactions
Volume	12
Issue number	4
DOIs	https://doi.org/10.1109/TLA.2014.6868857
State	Published - Jun 2014

Keywords

5-Aminolevulinic acid
Interstitial Photodynamic Therapy (IPDT)
laser diode
optical fiber

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10.1109/TLA.2014.6868857

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title = "Laser diode system for interstitial photodynamic therapy",

abstract = "Interstitial Photodynamic Therapy (IPDT) is a promising form of treatment of deep-seated and bulky malignant tumors, based on the lethal cell response to the photochemical reactions when drug is light activated at presence of oxygen. After intravenous administration, the drug is retained selectively by malignant cells, and then, the light is delivered to the target tissue through multiple optical fibers. In order to accomplish an effective internal illumination, laser sources are preferably used because of two important reasons: the laser beam is easily focused to optical fibers, and the monochromatic light can be confined to the narrow absorption band of the drug. In this work we present the design of an irradiation laser system, which involves a 635nm laser diode and a delivering fiber system, for 5-ALA mediated IPDT",

keywords = "5-Aminolevulinic acid, Interstitial Photodynamic Therapy (IPDT), laser diode, optical fiber",

author = "L. Pacheco and S. Stolik and {De La Rosa}, J. and {De La Cadena}, A.",

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T1 - Laser diode system for interstitial photodynamic therapy

AU - Pacheco, L.

AU - Stolik, S.

AU - De La Rosa, J.

AU - De La Cadena, A.

PY - 2014/6

Y1 - 2014/6

N2 - Interstitial Photodynamic Therapy (IPDT) is a promising form of treatment of deep-seated and bulky malignant tumors, based on the lethal cell response to the photochemical reactions when drug is light activated at presence of oxygen. After intravenous administration, the drug is retained selectively by malignant cells, and then, the light is delivered to the target tissue through multiple optical fibers. In order to accomplish an effective internal illumination, laser sources are preferably used because of two important reasons: the laser beam is easily focused to optical fibers, and the monochromatic light can be confined to the narrow absorption band of the drug. In this work we present the design of an irradiation laser system, which involves a 635nm laser diode and a delivering fiber system, for 5-ALA mediated IPDT

AB - Interstitial Photodynamic Therapy (IPDT) is a promising form of treatment of deep-seated and bulky malignant tumors, based on the lethal cell response to the photochemical reactions when drug is light activated at presence of oxygen. After intravenous administration, the drug is retained selectively by malignant cells, and then, the light is delivered to the target tissue through multiple optical fibers. In order to accomplish an effective internal illumination, laser sources are preferably used because of two important reasons: the laser beam is easily focused to optical fibers, and the monochromatic light can be confined to the narrow absorption band of the drug. In this work we present the design of an irradiation laser system, which involves a 635nm laser diode and a delivering fiber system, for 5-ALA mediated IPDT

KW - 5-Aminolevulinic acid

KW - Interstitial Photodynamic Therapy (IPDT)

KW - laser diode

KW - optical fiber

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DO - 10.1109/TLA.2014.6868857

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JO - IEEE Latin America Transactions

JF - IEEE Latin America Transactions

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Laser diode system for interstitial photodynamic therapy

Abstract

Keywords

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