TY - JOUR
T1 - Las células linfoides innatas y su papel en la regulación de la respuesta inmune
AU - Ruiz-Sánchez, Bibiana Patricia
AU - Cruz-Zárate, David
AU - Estrada-García, Iris
AU - Wong-Baeza, Isabel
N1 - Publisher Copyright:
© Nieto Editores. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology. ILC-2 express GATA3, produce IL-4, IL-5, IL-13 and amphiregulin, protect against parasitic infections and are related to allergy and obesity immunopathology. ILC-3 express ROR(γt), produce IL-17 and IL-22, protect against fungal infections and contribute to tolerance to intestinal microbiota and intestinal repair. They are related to inflammatory bowel disease and psoriasis immunopathology. In general terms, ILCs maintain homeostasis and coadjuvate in the protection against infections.
AB - Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology. ILC-2 express GATA3, produce IL-4, IL-5, IL-13 and amphiregulin, protect against parasitic infections and are related to allergy and obesity immunopathology. ILC-3 express ROR(γt), produce IL-17 and IL-22, protect against fungal infections and contribute to tolerance to intestinal microbiota and intestinal repair. They are related to inflammatory bowel disease and psoriasis immunopathology. In general terms, ILCs maintain homeostasis and coadjuvate in the protection against infections.
KW - Chronic inflammation
KW - Immune response
KW - Infection
KW - Innate lymphoid cells
UR - http://www.scopus.com/inward/record.url?scp=85050868937&partnerID=8YFLogxK
U2 - 10.29262/ram.v64i3.284
DO - 10.29262/ram.v64i3.284
M3 - Artículo
SN - 0002-5151
VL - 64
SP - 347
EP - 363
JO - Revista Alergia Mexico
JF - Revista Alergia Mexico
IS - 3
ER -