TY - JOUR
T1 - Lack of active Onchocerca volvulus transmission in the Northern Chiapas focus of Mexico
AU - Rodríguez-Pérez, Mario A.
AU - Unnasch, Thomas R.
AU - Domínguez-Vázquez, Alfredo
AU - Morales-Castro, Alba L.
AU - Richards, Frank
AU - Peña-Flores, Graciela P.
AU - Orozco-Algarra, María Eugenia
AU - Prado-Velasco, Gibert
PY - 2010/7
Y1 - 2010/7
N2 - The northern Chiapas onchocerciasis focus has undergone 11 years of ivermectin mass treatment. No evidence of microfilariae in the cornea and/or anterior chamber of the eye or in skin snips was seen in residents examined in 2006 in two sentinel communities (upper limit of the 95% confidence interval [UL 95% CI] = 0.5% and 0.3%, respectively). In children 10 and under, 0 of 305 were found to harbor antibodies to Ov16, a marker of parasite exposure; 0 of 4,400 Simulium ochraceum s.l. collected in 2005 contained parasite DNA, giving an UL 95% CI for the infective rate of 0.9/2,000, and an UL 95% CI of the seasonal transmission potential of 1.2 L3/person. These data, assumed to be representative of the focus as a whole, suggest that there is no ongoing transmission of Onchocerca volvulus in the northern Chiapas focus. Community-wide treatments with ivermectin were halted in 2008, and a post-treatment surveillance phase was initiated.
AB - The northern Chiapas onchocerciasis focus has undergone 11 years of ivermectin mass treatment. No evidence of microfilariae in the cornea and/or anterior chamber of the eye or in skin snips was seen in residents examined in 2006 in two sentinel communities (upper limit of the 95% confidence interval [UL 95% CI] = 0.5% and 0.3%, respectively). In children 10 and under, 0 of 305 were found to harbor antibodies to Ov16, a marker of parasite exposure; 0 of 4,400 Simulium ochraceum s.l. collected in 2005 contained parasite DNA, giving an UL 95% CI for the infective rate of 0.9/2,000, and an UL 95% CI of the seasonal transmission potential of 1.2 L3/person. These data, assumed to be representative of the focus as a whole, suggest that there is no ongoing transmission of Onchocerca volvulus in the northern Chiapas focus. Community-wide treatments with ivermectin were halted in 2008, and a post-treatment surveillance phase was initiated.
UR - http://www.scopus.com/inward/record.url?scp=77954576981&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2010.09-0626
DO - 10.4269/ajtmh.2010.09-0626
M3 - Artículo
C2 - 20595471
AN - SCOPUS:77954576981
SN - 0002-9637
VL - 83
SP - 15
EP - 20
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -
