TY - JOUR
T1 - La farmacocinética poblacional y su importancia en la terapéutica
AU - Barranco Garduño, Lina Marcela
AU - Neri Salvador, Juan Carlos
AU - León Molina, Héctor
AU - Carrasco Portugal, Miriam Del Carmen
AU - Flores Murrieta, Francisco Javier
AU - Patiño Camacho, Selene Isabel
PY - 2011/7
Y1 - 2011/7
N2 - Population pharmacokinetics has its main application in the study of the behavior of drugs, by estimating the average values of pharmacokinetic parameters in a group of individuals or a population of patients and the inter-individual variability associated with these parameters. The variability of drug response depends on various characteristics related to the pathophysiological situation of patients such as age, gender, weight, genetic factors, environmental factors, diseases, health status, etc. Population models provide an initial guide to develop dosing regimens to achieve and maintain a certain plasma concentration in each patient. The purpose of this review article is to understand the applications of population pharmacokinetic studies and identify the intrinsic and extrinsic characteristics that may influence the pharmacokinetics of the drugs tested.
AB - Population pharmacokinetics has its main application in the study of the behavior of drugs, by estimating the average values of pharmacokinetic parameters in a group of individuals or a population of patients and the inter-individual variability associated with these parameters. The variability of drug response depends on various characteristics related to the pathophysiological situation of patients such as age, gender, weight, genetic factors, environmental factors, diseases, health status, etc. Population models provide an initial guide to develop dosing regimens to achieve and maintain a certain plasma concentration in each patient. The purpose of this review article is to understand the applications of population pharmacokinetic studies and identify the intrinsic and extrinsic characteristics that may influence the pharmacokinetics of the drugs tested.
KW - Pharmacokinetic variability
KW - Population pharmacokinetic
UR - http://www.scopus.com/inward/record.url?scp=80052283604&partnerID=8YFLogxK
M3 - Artículo de revisión
SN - 0186-4866
VL - 27
SP - 370
EP - 377
JO - Medicina Interna de Mexico
JF - Medicina Interna de Mexico
IS - 4
ER -