TY - JOUR
T1 - La activación plaquetaria como factor desencadenante de la inflamación y la ateroesclerosis
AU - Custodio-Chablé, Santiago J.
AU - Lezama, Ruth A.
AU - Reyes-Maldonado, Elba
N1 - Publisher Copyright:
© 2020 Publicaciones Permanyer. All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - Platelets, in addition to participating in atherosclerosis, play a very active role in the immune response of this disease since they have the ability to interact with various inflammatory cells, in addition to secreting cytokines, chemokines, growth factors, etc. The functions of platelets go beyond their interaction with the endothelium, as they participate in creating an inflammatory environment, which contributes to the loss of homeostasis. On the other hand, platelet-derived microparticles induce the activation of other platelets, of endothelial cells and in recruiting leukocytes. For all the above, platelets and the inflammatory environment can be considered as possible therapeutic targets to prevent the development of atherosclerosis and the events associated with it.
AB - Platelets, in addition to participating in atherosclerosis, play a very active role in the immune response of this disease since they have the ability to interact with various inflammatory cells, in addition to secreting cytokines, chemokines, growth factors, etc. The functions of platelets go beyond their interaction with the endothelium, as they participate in creating an inflammatory environment, which contributes to the loss of homeostasis. On the other hand, platelet-derived microparticles induce the activation of other platelets, of endothelial cells and in recruiting leukocytes. For all the above, platelets and the inflammatory environment can be considered as possible therapeutic targets to prevent the development of atherosclerosis and the events associated with it.
KW - Atherosclerosis
KW - Inflammation
KW - Platelets
UR - http://www.scopus.com/inward/record.url?scp=85080840299&partnerID=8YFLogxK
U2 - 10.24875/CIRU.19000725
DO - 10.24875/CIRU.19000725
M3 - Artículo de revisión
C2 - 32116325
AN - SCOPUS:85080840299
SN - 0009-7411
VL - 88
SP - 233
EP - 243
JO - Cirugia y Cirujanos (English Edition)
JF - Cirugia y Cirujanos (English Edition)
IS - 2
ER -