TY - JOUR
T1 - Isothermal titration calorimetry
T2 - A thermodynamic interpretation of measurements
AU - Grolier, Jean Pierre E.
AU - Del Río, José Manuel
PY - 2012/12
Y1 - 2012/12
N2 - Isothermal titration calorimeters have been developed and in use since the 1960s and the number of applications based on empirical rules to use them steadily increases. In this paper a rigorous study of the physical interpretation of the titration heat and the thermodynamic framework underlying isothermal titration calorimetry are proposed. For infinitesimal titrations, the titration heat is independent of the cell type employed, and the interpretation of the titration heat depends on the titrant composition and on the experiment type. Moreover, for the study of the interaction between two solutes in solution, only a combination of two experiments is necessary, and the result is interpreted as the partial enthalpy of interaction at infinite dilution of the solute contained in the titrant solution.
AB - Isothermal titration calorimeters have been developed and in use since the 1960s and the number of applications based on empirical rules to use them steadily increases. In this paper a rigorous study of the physical interpretation of the titration heat and the thermodynamic framework underlying isothermal titration calorimetry are proposed. For infinitesimal titrations, the titration heat is independent of the cell type employed, and the interpretation of the titration heat depends on the titrant composition and on the experiment type. Moreover, for the study of the interaction between two solutes in solution, only a combination of two experiments is necessary, and the result is interpreted as the partial enthalpy of interaction at infinite dilution of the solute contained in the titrant solution.
KW - Calorimetry
KW - Enthalpy
KW - Isothermal titration calorimetry
KW - Partial properties
KW - Thermodynamics
UR - http://www.scopus.com/inward/record.url?scp=84865272521&partnerID=8YFLogxK
U2 - 10.1016/j.jct.2012.05.018
DO - 10.1016/j.jct.2012.05.018
M3 - Artículo
AN - SCOPUS:84865272521
SN - 0021-9614
VL - 55
SP - 193
EP - 202
JO - The Journal of Chemical Thermodynamics
JF - The Journal of Chemical Thermodynamics
ER -