TY - JOUR
T1 - Isosakuranetin-5-O-rutinoside
T2 - A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl
AU - González-Cortazar, Manáses
AU - Maldonado-Abarca, Ana María
AU - Jiménez-Ferrer, Enrique
AU - Marquina, Silvia
AU - Ventura-Zapata, Elsa
AU - Zamilpa, Alejandro
AU - Tortoriello, Jaime
AU - Herrera-Ruiz, Maribel
PY - 2013/11
Y1 - 2013/11
N2 - Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy- 4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
AB - Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy- 4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
KW - Antidepressant activity
KW - Flavanone
KW - Isosakuranetin
KW - NMR
KW - Rutinoside
KW - Salvia elegans
KW - Ursolic acid
UR - http://www.scopus.com/inward/record.url?scp=84888617512&partnerID=8YFLogxK
U2 - 10.3390/molecules181113260
DO - 10.3390/molecules181113260
M3 - Artículo
C2 - 24165584
AN - SCOPUS:84888617512
SN - 1420-3049
VL - 18
SP - 13260
EP - 13270
JO - Molecules
JF - Molecules
IS - 11
ER -