TY - JOUR
T1 - Isolation of IgG antibodies to Toxocara in ankylosing spondylitis patients with acute anterior uveitis
AU - Jiménez-Balderas, Francisco Javier
AU - García-Jaimes, Janete
AU - Ríos, Rita
AU - Zonana-Nacach, Abraham
AU - Tapia-Romero, Raquel
AU - Villanueva, Nayeli
AU - Méndez-Samperio, Patricia
AU - de-la-Rosa-Arana, Jorge Luis
PY - 2014/6/1
Y1 - 2014/6/1
N2 - PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU.METHODS: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions.RESULTS: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS.CONCLUSIONS: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
AB - PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU.METHODS: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions.RESULTS: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS.CONCLUSIONS: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
KW - Ankylosing-spondylitis
KW - Anterior-uveitis
KW - Toxocariasis
UR - http://www.scopus.com/inward/record.url?scp=84965093776&partnerID=8YFLogxK
U2 - 10.3341/kjo.2014.28.3.207
DO - 10.3341/kjo.2014.28.3.207
M3 - Artículo
C2 - 24882953
SN - 1011-8942
VL - 28
SP - 207
EP - 212
JO - Korean journal of ophthalmology : KJO
JF - Korean journal of ophthalmology : KJO
IS - 3
ER -