Abstract
Hypoglycemic activity-guided fractionation together with chemical analysis led to the isolation of one flavone (5, 7,3'-trihydroxy-3,6,4'- trimethoxyflavone) from the chloroform extract of the leaves of Brikkellia veronicaefolia. Identification was based on spectroscopic methods. The isolated flavone was tested for hypoglycemic activity in normal and alloxan- diabetic CD1 mice (25-30 g) were administered in doses of 10, 25 and 50 mg/kg body weight. The blood glucose levels were determined before and 1.5, 3, 4.5 and 24 hours after drug administration. The results showed that the flavone produces a significant hypoglycemic effect in normal as well as in diabetic mice. Comparison was made between the action of the flavone and a known hypoglycemic drug as tolbutamide (50 mg/kg). The flavone was found to be slow and less effective than tolbutamide.
Original language | English |
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Pages (from-to) | 25-29 |
Number of pages | 5 |
Journal | Phytomedicine |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2000 |
Externally published | Yes |
Keywords
- Brickellia veronicaefolia
- Flavone, 5, 7,3'- trihydroxy-3,6,4'-trimethoxyflavone
- Hypoglycemic activity