Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits

Gustavo Puras; Virgilio Bocanegra García; Gildardo Rivera

Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits

Gustavo Puras, Virgilio Bocanegra García, Gildardo Rivera

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the present work was to compare the effect of α-ergocryptine on the intraocular pressure (IOP) and aqueous humor (AH) dynamics in ocular normotensive and α-chymotrypsin-induced ocular hypertensive rabbits. Our data suggest that α-ergocryptine decreases both tonographic outflow facility and, to a greater extent, AH inflow, which explains the final effect in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits. Reductions in AH inflow observed after topical application of α-ergocryptine in α-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of AH, since processes involved in AH formation, may be probably altered after α-chymotrypsin injection.

Original language	English
Pages (from-to)	22-29
Number of pages	8
Journal	Revista Mexicana de Ciencias Farmaceuticas
Volume	40
Issue number	4
State	Published - Oct 2009
Externally published	Yes

Keywords

Aqueous Humor (AH)
Intraocular Pressure (IOP)
α-chymotrypsin
α-ergocryptine

Cite this

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title = "Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits",

abstract = "The aim of the present work was to compare the effect of α-ergocryptine on the intraocular pressure (IOP) and aqueous humor (AH) dynamics in ocular normotensive and α-chymotrypsin-induced ocular hypertensive rabbits. Our data suggest that α-ergocryptine decreases both tonographic outflow facility and, to a greater extent, AH inflow, which explains the final effect in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits. Reductions in AH inflow observed after topical application of α-ergocryptine in α-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of AH, since processes involved in AH formation, may be probably altered after α-chymotrypsin injection.",

keywords = "Aqueous Humor (AH), Intraocular Pressure (IOP), α-chymotrypsin, α-ergocryptine",

author = "Gustavo Puras and Garc{\'i}a, {Virgilio Bocanegra} and Gildardo Rivera",

year = "2009",

month = oct,

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pages = "22--29",

journal = "Revista Mexicana de Ciencias Farmaceuticas",

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Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits. / Puras, Gustavo; García, Virgilio Bocanegra ; Rivera, Gildardo.
In: Revista Mexicana de Ciencias Farmaceuticas, Vol. 40, No. 4, 10.2009, p. 22-29.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits

AU - Puras, Gustavo

AU - García, Virgilio Bocanegra

AU - Rivera, Gildardo

PY - 2009/10

Y1 - 2009/10

N2 - The aim of the present work was to compare the effect of α-ergocryptine on the intraocular pressure (IOP) and aqueous humor (AH) dynamics in ocular normotensive and α-chymotrypsin-induced ocular hypertensive rabbits. Our data suggest that α-ergocryptine decreases both tonographic outflow facility and, to a greater extent, AH inflow, which explains the final effect in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits. Reductions in AH inflow observed after topical application of α-ergocryptine in α-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of AH, since processes involved in AH formation, may be probably altered after α-chymotrypsin injection.

AB - The aim of the present work was to compare the effect of α-ergocryptine on the intraocular pressure (IOP) and aqueous humor (AH) dynamics in ocular normotensive and α-chymotrypsin-induced ocular hypertensive rabbits. Our data suggest that α-ergocryptine decreases both tonographic outflow facility and, to a greater extent, AH inflow, which explains the final effect in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits. Reductions in AH inflow observed after topical application of α-ergocryptine in α-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of AH, since processes involved in AH formation, may be probably altered after α-chymotrypsin injection.

KW - Aqueous Humor (AH)

KW - Intraocular Pressure (IOP)

KW - α-chymotrypsin

KW - α-ergocryptine

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M3 - Artículo

SN - 1027-3956

VL - 40

SP - 22

EP - 29

JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

IS - 4

ER -

Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits

Abstract

Keywords

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