TY - JOUR
T1 - Interactions of host miRNAs in the flavivirus 3´UTR genome
T2 - From bioinformatics predictions to practical approaches
AU - Avila-Bonilla, Rodolfo Gamaliel
AU - Salas-Benito, Juan Santiago
N1 - Publisher Copyright:
Copyright © 2022 Avila-Bonilla and Salas-Benito.
PY - 2022/10/13
Y1 - 2022/10/13
N2 - The genus Flavivirus of the Flaviviridae family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic cells synthesize small RNA molecules that can bind specifically to sequences present in messenger RNAs to inhibit the translation process, thus regulating gene expression. These small RNAs have been named microRNAs, and they have an important impact on viral infections. In this review, we compiled the available information on miRNAs that can interact with the 3’ untranslated region (3’UTR) of the flavivirus genome, a conserved region that is important for viral replication and translation.
AB - The genus Flavivirus of the Flaviviridae family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic cells synthesize small RNA molecules that can bind specifically to sequences present in messenger RNAs to inhibit the translation process, thus regulating gene expression. These small RNAs have been named microRNAs, and they have an important impact on viral infections. In this review, we compiled the available information on miRNAs that can interact with the 3’ untranslated region (3’UTR) of the flavivirus genome, a conserved region that is important for viral replication and translation.
KW - MicroRNAs
KW - antivirals
KW - arthropod-borne viruses
KW - non-translated regions
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85140769054&partnerID=8YFLogxK
U2 - 10.3389/fcimb.2022.976843
DO - 10.3389/fcimb.2022.976843
M3 - Artículo de revisión
C2 - 36310869
AN - SCOPUS:85140769054
SN - 2235-2988
VL - 12
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 976843
ER -