TY - JOUR
T1 - Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
AU - Soba, Alejandro
AU - Suárez, Cecilia
AU - González, Maraelys Morales
AU - Cabrales, Luis Enrique Bergues
AU - Pupo, Ana Elisa Bergues
AU - Reyes, Juan Bory
AU - Martínez Tassé, José Pablo
N1 - Publisher Copyright:
© 2017 International Association for Mathematics and Computers in Simulation (IMACS)
PY - 2018/4
Y1 - 2018/4
N2 - The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In this paper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together with the acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arrays for a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes of electrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, are solved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly on the electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. The numerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permits to make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted.
AB - The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In this paper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together with the acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arrays for a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes of electrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, are solved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly on the electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. The numerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permits to make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted.
KW - Electric field intensity
KW - Electrode arrays
KW - Tissue damage
KW - pH fronts
UR - http://www.scopus.com/inward/record.url?scp=85038819009&partnerID=8YFLogxK
U2 - 10.1016/j.matcom.2017.11.006
DO - 10.1016/j.matcom.2017.11.006
M3 - Artículo
AN - SCOPUS:85038819009
SN - 0378-4754
VL - 146
SP - 160
EP - 176
JO - Mathematics and Computers in Simulation
JF - Mathematics and Computers in Simulation
ER -