TY - JOUR
T1 - Inhibitory effect of Spirulina maxima on the azoxymethaneinduced aberrant colon crypts and oxidative damage in mice
AU - Álvarez-González, Isela
AU - Islas-Islas, Víctor
AU - Chamorro-Cevallos, Germán
AU - Barrios, Juan Pablo
AU - Paniagua, Norma
AU - Vásquez-Garzón, Verónica R.
AU - Villa-Treviño, Saúl
AU - Osiris-Madrigal-Santillán,
AU - Morales-González, José Antonio
AU - Madrigal-Bujaidar, Eduardo
N1 - Publisher Copyright:
© 2015 Pharmacognosy Magazine | Published by Wolters Kluwer - Medknow.
PY - 2015/10
Y1 - 2015/10
N2 - Background: Spirulina maxima (Sm) is a cyanobacterium well known because of its high nutritive value, as well as its anti-inflammatory, anti-hyperlipidemic, antioxidant, and anti-genotoxic activities. Objective: To determine the capacity of Sm to inhibit the induction of aberrant colon crypts (AC), as well as the level of lipid peroxidation and DNA oxidative damage in mice treated with azoxymethane (AOM). Materials and Methods: Sm (100, 400, and 800 mg/kg) was daily administered to animals by the oral route during 4 weeks, while AOM (10 mg/kg) was intraperitoneally injected to mice twice in weeks 2 and 3 of the assay. We also included a control group of mice orally administered with distilled water along the assay, as well as other group orally administered with the high dose of Sm. Results: A significant decrease in the number of AC with the three tested doses of Sm, with a mean protection of 51.6% respect to the damage induced by AOM. Also, with the three doses of the alga, we found a reduction in the level of lipoperoxidation, as well as in regard to the percentage of the DNA adduct 8-hydroxy-2'-deoxyguanosine. Conclusion: Sm possesses anti-precarcinogenic potential in vivo, as well as capacity to reduce the oxidative damage induced by AOM.
AB - Background: Spirulina maxima (Sm) is a cyanobacterium well known because of its high nutritive value, as well as its anti-inflammatory, anti-hyperlipidemic, antioxidant, and anti-genotoxic activities. Objective: To determine the capacity of Sm to inhibit the induction of aberrant colon crypts (AC), as well as the level of lipid peroxidation and DNA oxidative damage in mice treated with azoxymethane (AOM). Materials and Methods: Sm (100, 400, and 800 mg/kg) was daily administered to animals by the oral route during 4 weeks, while AOM (10 mg/kg) was intraperitoneally injected to mice twice in weeks 2 and 3 of the assay. We also included a control group of mice orally administered with distilled water along the assay, as well as other group orally administered with the high dose of Sm. Results: A significant decrease in the number of AC with the three tested doses of Sm, with a mean protection of 51.6% respect to the damage induced by AOM. Also, with the three doses of the alga, we found a reduction in the level of lipoperoxidation, as well as in regard to the percentage of the DNA adduct 8-hydroxy-2'-deoxyguanosine. Conclusion: Sm possesses anti-precarcinogenic potential in vivo, as well as capacity to reduce the oxidative damage induced by AOM.
KW - Azoxymethane
KW - Chemoprevention
KW - Colon damage
KW - Mice
KW - Spirulina
UR - http://www.scopus.com/inward/record.url?scp=84975783905&partnerID=8YFLogxK
U2 - 10.4103/0973-1296.172973
DO - 10.4103/0973-1296.172973
M3 - Artículo
C2 - 27013804
SN - 0973-1296
VL - 11
SP - 619
EP - 624
JO - Pharmacognosy Magazine
JF - Pharmacognosy Magazine
IS - 44
ER -