TY - JOUR
T1 - Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents
AU - Picazo, Ofir
AU - Estrada-Camarena, Erika
AU - Hernandez-Aragon, Azucena
N1 - Funding Information:
This study was partially supported by CGPI-IPN and COFAA. A. H-A. received a fellowship from CONACYT.
PY - 2006/1/13
Y1 - 2006/1/13
N2 - This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour paradigm and in an automatic activity counter. The highest values of time spent burying were observed in the 12-week group. In general, the 12-week group was more responsive to diazepam than the 3-week group, while 8-OH-DPAT showed similar effects on time spent burying, independently of how long ago the ovariectomy was done. Detection of anxiogenic-like behaviours by the shock-probe burying test in rats after chronic absence of gonadal hormones could help in the understanding of mood changes associated with human menopause.
AB - This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour paradigm and in an automatic activity counter. The highest values of time spent burying were observed in the 12-week group. In general, the 12-week group was more responsive to diazepam than the 3-week group, while 8-OH-DPAT showed similar effects on time spent burying, independently of how long ago the ovariectomy was done. Detection of anxiogenic-like behaviours by the shock-probe burying test in rats after chronic absence of gonadal hormones could help in the understanding of mood changes associated with human menopause.
KW - 8-OH-DPAT
KW - Anxiety
KW - Burying behaviour
KW - Diazepam
KW - Menopause
KW - Ovariectomy
UR - http://www.scopus.com/inward/record.url?scp=29844445335&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2005.11.024
DO - 10.1016/j.ejphar.2005.11.024
M3 - Artículo
C2 - 16356491
SN - 0014-2999
VL - 530
SP - 88
EP - 94
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -