TY - JOUR
T1 - Influence of CYP1A1*2C on High Triglyceride Levels in Female Mexican Indigenous Tarahumaras
AU - Bailón-Soto, Claudia E.
AU - Galaviz-Hernández, Carlos
AU - Lazalde-Ramos, Blanca P.
AU - Hernández-Velázquez, Daniel
AU - Salas-Pacheco, José
AU - Lares-Assef, Ismael
AU - Sosa-Macías, Martha
N1 - Funding Information:
We wish to express our gratitude to all the indigenous volunteers for their collaboration despite the language barrier. We also wish to thank the Molecular Biology Laboratory staff from CIIDIR-DURANGO for all the facilities given, especially to Margarita Ortega, M.S., and the laboratory chief Dr. Carlos Galaviz Hernández. We wish to thank CONACYT-Mexico for the scholarship granted to Claudia Edith Bailón Soto. This study was supported by CONACYT-Mexico Project ( 2011-C01-162368 ) and by the SIP IPN Project ( 20131835 ). Dr. Martha Sosa-Macías is supported by a grant (COFAA) from the Instituto Politécnico Nacional .
PY - 2014/7
Y1 - 2014/7
N2 - Background and Aims: High triglyceride levels are closely related to cardiovascular disease. Its development lays on age, diet, physical activity, ethnicity and genetic factors. Among the last, the CYP1A1*2C allele has an influence on the metabolism of cholesterol and other fatty acids. We undertook this study to determine the frequency of CYP1A1*2C and its association with triglyceride levels in Mexican indigenous Tarahumaras and Tepehuanos. Methods: Anthropometric and biochemical data were recorded. Genotyping of CYP1A1*2C by RT-PCR was done in 110 Tepehuano, 69 Tarahumara and 64 Mestizo. Results: Significant differences in age, waist diameter, BMI, creatinine, glucose, cholesterol, triglycerides, HDL and VLDL measurements were found between Tarahumaras and Tepehuanos (p <0.05). Additionally, Tarahumara women showed the highest values of waist diameter, BMI and triglycerides (p <0.05). It was found that Tarahumaras showed a significant association between high triglyceride levels and CYP1A1*2C allele (OR = 2.57; 95% CI 1.12-5.88, p = 0.024) under a recessive inheritance model. However, the Tepehuano group showed a significant protective association between normal triglyceride levels and CYP1A1*2C polymorphism (OR = 0.28; 95% CI 0.10-0.80, p = 0.015) following a dominant inheritance model. The same pattern was observed after analysis with females of both ethnicities. Conclusion: A significant association between CYP1A1*2C and high triglyceride levels in Amerindian Tarahumaras from Chihuahua has been found; this allele was significantly associated with normal triglyceride levels in Tepehuanos from Durango, Mexico. Further studies are needed to elucidate the genetic role of CYP1A1 in cardiovascular disease susceptibility.
AB - Background and Aims: High triglyceride levels are closely related to cardiovascular disease. Its development lays on age, diet, physical activity, ethnicity and genetic factors. Among the last, the CYP1A1*2C allele has an influence on the metabolism of cholesterol and other fatty acids. We undertook this study to determine the frequency of CYP1A1*2C and its association with triglyceride levels in Mexican indigenous Tarahumaras and Tepehuanos. Methods: Anthropometric and biochemical data were recorded. Genotyping of CYP1A1*2C by RT-PCR was done in 110 Tepehuano, 69 Tarahumara and 64 Mestizo. Results: Significant differences in age, waist diameter, BMI, creatinine, glucose, cholesterol, triglycerides, HDL and VLDL measurements were found between Tarahumaras and Tepehuanos (p <0.05). Additionally, Tarahumara women showed the highest values of waist diameter, BMI and triglycerides (p <0.05). It was found that Tarahumaras showed a significant association between high triglyceride levels and CYP1A1*2C allele (OR = 2.57; 95% CI 1.12-5.88, p = 0.024) under a recessive inheritance model. However, the Tepehuano group showed a significant protective association between normal triglyceride levels and CYP1A1*2C polymorphism (OR = 0.28; 95% CI 0.10-0.80, p = 0.015) following a dominant inheritance model. The same pattern was observed after analysis with females of both ethnicities. Conclusion: A significant association between CYP1A1*2C and high triglyceride levels in Amerindian Tarahumaras from Chihuahua has been found; this allele was significantly associated with normal triglyceride levels in Tepehuanos from Durango, Mexico. Further studies are needed to elucidate the genetic role of CYP1A1 in cardiovascular disease susceptibility.
KW - CYP1A1
KW - High triglyceride levels
KW - Tarahumaras
KW - Tepehuanos
UR - http://www.scopus.com/inward/record.url?scp=84904674116&partnerID=8YFLogxK
U2 - 10.1016/j.arcmed.2014.05.007
DO - 10.1016/j.arcmed.2014.05.007
M3 - Artículo
C2 - 24945098
SN - 0188-4409
VL - 45
SP - 409
EP - 416
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 5
ER -