TY - JOUR
T1 - Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico
AU - Sosa-Macías, M.
AU - Lazalde-Ramos, B. P.
AU - Galaviz-Hernández, C.
AU - Rangel-Villalobos, H.
AU - Salazar-Flores, J.
AU - Martínez-Sevilla, V. M.
AU - Martínez-Fierro, M. L.
AU - Dorado, P.
AU - Wong, M. L.
AU - Licinio, J.
AU - Llerena, A.
N1 - Funding Information:
This study was supported by CONACYT-Mexico Project 2009-01-113063. This study was partially supported by the Institute of Health Carlos III-FIS and the European Union (FEDER) Grants PI10/02010, PI10/02758 and CP06/00030 (P Dorado) and Gobierno de Extremadura AEXCID Cooperación Extremeña (11IA002). The study was coordinated in the RIBEF-SIFF network (Red Iberoamericana de Farmacogenética y Farmacogenómica; www.ribef.com) Consortium CEIBA for the Study of Pharmacogenetics of Iberoamerican Populations.
PY - 2013/12
Y1 - 2013/12
N2 - We previously documented the lowest frequency of CYP2C9*2 in Mexican indigenous Tepehuanos followed by Mestizos and Mexican-Americans populations, suggesting a negative correlation between the CYP2C9*2 frequency and the degree of Asian ancestry in indigenous Americans. We determined the influence of ethnic admixture components on the CYP2C9 allele distribution in 505 Amerindian from eight indigenous populations through genotyping CYP2C9*2, *3 and *6 alleles by real-time PCR and molecular evaluation of ancestry. The frequencies for CYP2C9*2 were 0.026 in Seris and 0.057 in Mayos, being higher than in Asians (P<0.001). CYP2C9*3 was found in Tarahumaras (0.104), Mayos (0.091), Tepehuanos (0.075), Guarijíos (0.067), Huicholes (0.033) and Coras (0.037), with East Asians having lower frequencies than the former three groups (P<0.001). CYP2C9*6 was not found. The frequency of CYP2C9*2 was lower in Amerindians than in European populations, and higher than their Asian ancestors. The presence of this allele in ethnic groups in Mexico can be explained by European admixture.
AB - We previously documented the lowest frequency of CYP2C9*2 in Mexican indigenous Tepehuanos followed by Mestizos and Mexican-Americans populations, suggesting a negative correlation between the CYP2C9*2 frequency and the degree of Asian ancestry in indigenous Americans. We determined the influence of ethnic admixture components on the CYP2C9 allele distribution in 505 Amerindian from eight indigenous populations through genotyping CYP2C9*2, *3 and *6 alleles by real-time PCR and molecular evaluation of ancestry. The frequencies for CYP2C9*2 were 0.026 in Seris and 0.057 in Mayos, being higher than in Asians (P<0.001). CYP2C9*3 was found in Tarahumaras (0.104), Mayos (0.091), Tepehuanos (0.075), Guarijíos (0.067), Huicholes (0.033) and Coras (0.037), with East Asians having lower frequencies than the former three groups (P<0.001). CYP2C9*6 was not found. The frequency of CYP2C9*2 was lower in Amerindians than in European populations, and higher than their Asian ancestors. The presence of this allele in ethnic groups in Mexico can be explained by European admixture.
KW - CYP2C9
KW - Mexican indigenous
KW - ancestral components
KW - pharmacogenetics
UR - http://www.scopus.com/inward/record.url?scp=84888133570&partnerID=8YFLogxK
U2 - 10.1038/tpj.2012.52
DO - 10.1038/tpj.2012.52
M3 - Artículo
C2 - 23358499
SN - 1470-269X
VL - 13
SP - 567
EP - 572
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
IS - 6
ER -