TY - JOUR
T1 - Increased antidepressant-like effect of desipramine combined with central stimulants (caffeine and amphetamine) in mice
AU - Robles-Molina, Evelyn
AU - Millán, Daniel
AU - Hong, Enrique
AU - Huang, Fengyang
AU - Villafaña, Santiago
PY - 2012/6
Y1 - 2012/6
N2 - Desipramine is a widely used antidepressive agent that inhibits the reuptake of noradrenaline and serotonin, and central stimulants such as caffeine and amphetamine help to release noradrenaline and serotonin. This work aimed to evaluate whether the combination of these agents could produce a stronger antidepressant-like effect than either of the drugs alone. To this end, male mice were treated with different doses of desipramine, caffeine, amphetamine, desipramine-caffeine and desipramine-amphetamine. The results showed that all drugs produced decreased immobility time in the forced swimming model. The combined treatment of desipramine (0.31, 1.0 or 3.1 mg/kg i. p.) with caffeine or amphetamine (0.31 or 1 mg/kg i. p.) reduced immobility time greater than either of those drugs alone. The combined treatment of desipramine (0.31, 1 and 3.1 mg/kg i. p.) with amphetamine or caffeine (0.1 and 1 mg/kg i. p.) did not increase the motor activity significantly compared to the control. These results also suggested that drugs which promote the release of noradrenaline and serotonin could increase antidepressant-like effect of desipramine.
AB - Desipramine is a widely used antidepressive agent that inhibits the reuptake of noradrenaline and serotonin, and central stimulants such as caffeine and amphetamine help to release noradrenaline and serotonin. This work aimed to evaluate whether the combination of these agents could produce a stronger antidepressant-like effect than either of the drugs alone. To this end, male mice were treated with different doses of desipramine, caffeine, amphetamine, desipramine-caffeine and desipramine-amphetamine. The results showed that all drugs produced decreased immobility time in the forced swimming model. The combined treatment of desipramine (0.31, 1.0 or 3.1 mg/kg i. p.) with caffeine or amphetamine (0.31 or 1 mg/kg i. p.) reduced immobility time greater than either of those drugs alone. The combined treatment of desipramine (0.31, 1 and 3.1 mg/kg i. p.) with amphetamine or caffeine (0.1 and 1 mg/kg i. p.) did not increase the motor activity significantly compared to the control. These results also suggested that drugs which promote the release of noradrenaline and serotonin could increase antidepressant-like effect of desipramine.
KW - Amphetamine
KW - Caffeine
KW - Depression
KW - Desipramine
KW - Forced swimming test
UR - http://www.scopus.com/inward/record.url?scp=84859337636&partnerID=8YFLogxK
U2 - 10.2478/s11535-012-0028-1
DO - 10.2478/s11535-012-0028-1
M3 - Artículo
SN - 1895-104X
VL - 7
SP - 391
EP - 396
JO - Central European Journal of Biology
JF - Central European Journal of Biology
IS - 3
ER -