In silico and in vitro studies to elucidate the role of Cu²⁺ and galanthamine as the limiting step in the amyloid beta (1-42) fibrillation process

Medicine & Life Sciences

• Galantamine 93%
• amyloid beta-protein (1-42) 88%
• Computer Simulation 60%
• Molecular Dynamics Simulation 56%
• Salts 33%
• In Vitro Techniques 27%
• Alzheimer Disease 19%
• Ligands 18%
• Amino Acids 17%
• Circular Dichroism 15%
• Spectrum Analysis 12%
• Amyloid 12%
• Psychological Inhibition 10%
• Fluorescence 10%
• Pharmaceutical Preparations 5%

Chemistry

• Galanthamine 100%
• Beta-Amyloid 71%
• Molecular Dynamics 37%
• Simulation 32%
• Oligomer 30%
• Alzheimer Disease Treatment 20%
• Amino-Acid Residue 11%
• Ligand 11%
• Circular Dichroism 10%
• Monomer 7%
• Fluorescence 7%
• Drug 6%
• Acid 4%