TY - JOUR
T1 - In Silico Analysis of Potential Drug Targets for Protozoan Infections
AU - Juárez-Saldivar, Alfredo
AU - Campillo, Nuria E.
AU - Ortiz-Perez, Eyra
AU - Paz-Gonzalez, Alma D.
AU - Saavedra, Emma
AU - Rivera, Gildardo
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023/1
Y1 - 2023/1
N2 - Background: Currently, protozoan infectious diseases affect billions of people every year. Their pharmacological treatments offer few alternatives and are restrictive due to undesirable side effects and parasite drug resistance. Objective: In this work, three ontology-based approaches were used to identify shared potential drug targets in five species of protozoa. Methods: In this study, proteomes of five species of protozoa: Entamoeba histolytica (E. histolytica), Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), Trypanosoma cruzi (T. cruzi), and Leishmania mexicana (L. mexicana), were compared through orthology inference using three different tools to identify potential drug targets. Results: Comparing the proteomes of E. histolytica, G. lamblia, T. vaginalis, T. cruzi, and L. mexi-cana, twelve targets for developing new drugs with antiprotozoal activity were identified. Conclusion: New drug targets were identified by orthology-based analysis; therefore, they could be considered for the development of new broad-spectrum antiprotozoal drugs. Particularly, triosephos-phate isomerase emerges as a common target in trypanosomatids and amitochondriate parasites.
AB - Background: Currently, protozoan infectious diseases affect billions of people every year. Their pharmacological treatments offer few alternatives and are restrictive due to undesirable side effects and parasite drug resistance. Objective: In this work, three ontology-based approaches were used to identify shared potential drug targets in five species of protozoa. Methods: In this study, proteomes of five species of protozoa: Entamoeba histolytica (E. histolytica), Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), Trypanosoma cruzi (T. cruzi), and Leishmania mexicana (L. mexicana), were compared through orthology inference using three different tools to identify potential drug targets. Results: Comparing the proteomes of E. histolytica, G. lamblia, T. vaginalis, T. cruzi, and L. mexi-cana, twelve targets for developing new drugs with antiprotozoal activity were identified. Conclusion: New drug targets were identified by orthology-based analysis; therefore, they could be considered for the development of new broad-spectrum antiprotozoal drugs. Particularly, triosephos-phate isomerase emerges as a common target in trypanosomatids and amitochondriate parasites.
KW - Drug target
KW - amitochondriates
KW - infectious disease
KW - orthology
KW - protozoa
KW - trypanosomatid
UR - http://www.scopus.com/inward/record.url?scp=85143283752&partnerID=8YFLogxK
U2 - 10.2174/1573406418666220816121912
DO - 10.2174/1573406418666220816121912
M3 - Artículo
C2 - 35975866
AN - SCOPUS:85143283752
SN - 1573-4064
VL - 19
SP - 91
EP - 98
JO - Medicinal Chemistry
JF - Medicinal Chemistry
IS - 1
ER -