Impact of tetramerization on the ligand recognition of N1 influenza neuraminidase via MMGBSA approach

Chemistry

• Sialic Acid 83%
• Oseltamivir Acid 81%
• Oseltamivir 59%
• Simulation 47%
• Drug 39%
• Ligand 33%
• Mutation 31%
• Enzyme Activity 31%
• Flexibility 30%
• Kd 28%
• Protein 15%
• Surface 11%

Medicine & Life Sciences

• Neuraminidase 85%
• Human Influenza 69%
• Ligands 53%
• Oseltamivir 51%
• N-Acetylneuraminic Acid 43%
• Drug Design 43%
• Orthomyxoviridae 19%
• Catalytic Domain 17%
• Membrane Proteins 15%
• Costs and Cost Analysis 11%
• Mutation 10%

Engineering & Materials Science

• Ligands 100%
• Acids 68%
• Viruses 44%
• Proteins 34%
• Substrates 26%
• Costs 14%