TY - JOUR
T1 - Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women
T2 - A pilot study
AU - Moreno-Galván, Mónica
AU - Herrera-González, Norma Estela
AU - Robles-Pérez, Vera
AU - Velasco-Rodríguez, Julio C.
AU - Tapia-Conyer, Roberto
AU - Sarti, Elsa
PY - 2010
Y1 - 2010
N2 - Background: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. Objective: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. Material and methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP. Results: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found. Conclusions: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
AB - Background: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. Objective: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. Material and methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP. Results: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found. Conclusions: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
KW - Biomarkers
KW - Breast cancer
KW - CYP1A1 gene polymorphism
UR - http://www.scopus.com/inward/record.url?scp=78650833481&partnerID=8YFLogxK
U2 - 10.1177/172460081002500306
DO - 10.1177/172460081002500306
M3 - Artículo
SN - 0393-6155
VL - 25
SP - 157
EP - 163
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
IS - 3
ER -