Abstract
Immunization of mice with the B oligomer of pertussis toxin induced antibodies to the native toxin as measured by an enzyme-linked immunosorbent assay. These antibodies neutralized the ability of pertussis toxin to alter the morphology of Chinese hamster ovary cells. Furthermore, mice immunized with the B oligomer, when challenged with pertussis toxin, did not exhibit the leukocytosis normally associated with exposure to the toxin. These results demonstrate that the B oligomer, which does not contain the enzymatic activity of the holotoxin, can be used to introduce a neutralizing antibody response and suggest that the B oligomer might be considered for use in acellular pertussis vaccine.
Original language | English |
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Pages (from-to) | 1132-1136 |
Number of pages | 5 |
Journal | Infection and Immunity |
Volume | 55 |
Issue number | 5 |
State | Published - 1987 |
Externally published | Yes |