IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients

Danelia Mendieta; Dora Luz De la Cruz-Aguilera; Maria Isabel Barrera-Villalpando; Enrique Becerril-Villanueva; Rodrigo Arreola; Erick Hernández-Ferreira; Sonia Mayra Pérez-Tapia; Gilberto Pérez-Sánchez; María Eugenia Garcés-Alvarez; Lucinda Aguirre-Cruz; Marco Antonio Velasco-Velázquez; Lenin Pavón

doi:10.1016/j.jneuroim.2015.11.011

IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients

Danelia Mendieta, Dora Luz De la Cruz-Aguilera, Maria Isabel Barrera-Villalpando, Enrique Becerril-Villanueva, Rodrigo Arreola, Erick Hernández-Ferreira, Sonia Mayra Pérez-Tapia, Gilberto Pérez-Sánchez, María Eugenia Garcés-Alvarez, Lucinda Aguirre-Cruz, Marco Antonio Velasco-Velázquez, Lenin Pavón

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.

Original language	English
Pages (from-to)	22-25
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	290
DOIs	https://doi.org/10.1016/j.jneuroim.2015.11.011
State	Published - 15 Jan 2016

Keywords

FIQ
Fibromyalgia
IL-6
IL-8
Inflammation

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Mendieta, D., la Cruz-Aguilera, D. L. D., Barrera-Villalpando, M. I., Becerril-Villanueva, E., Arreola, R., Hernández-Ferreira, E., Pérez-Tapia, S. M., Pérez-Sánchez, G., Garcés-Alvarez, M. E., Aguirre-Cruz, L., Velasco-Velázquez, M. A., & Pavón, L. (2016). IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients. Journal of Neuroimmunology, 290, 22-25. https://doi.org/10.1016/j.jneuroim.2015.11.011

@article{834cb96281854241a9bc0b5070ba86e4,

title = "IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients",

abstract = "Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.",

keywords = "FIQ, Fibromyalgia, IL-6, IL-8, Inflammation",

author = "Danelia Mendieta and {la Cruz-Aguilera}, {Dora Luz De} and Barrera-Villalpando, {Maria Isabel} and Enrique Becerril-Villanueva and Rodrigo Arreola and Erick Hern{\'a}ndez-Ferreira and P{\'e}rez-Tapia, {Sonia Mayra} and Gilberto P{\'e}rez-S{\'a}nchez and Garc{\'e}s-Alvarez, {Mar{\'i}a Eugenia} and Lucinda Aguirre-Cruz and Velasco-Vel{\'a}zquez, {Marco Antonio} and Lenin Pav{\'o}n",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2016",

month = jan,

day = "15",

doi = "10.1016/j.jneuroim.2015.11.011",

language = "Ingl{\'e}s",

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pages = "22--25",

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Mendieta, D, la Cruz-Aguilera, DLD, Barrera-Villalpando, MI, Becerril-Villanueva, E, Arreola, R, Hernández-Ferreira, E, Pérez-Tapia, SM, Pérez-Sánchez, G, Garcés-Alvarez, ME, Aguirre-Cruz, L, Velasco-Velázquez, MA & Pavón, L 2016, 'IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients', Journal of Neuroimmunology, vol. 290, pp. 22-25. https://doi.org/10.1016/j.jneuroim.2015.11.011

TY - JOUR

T1 - IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients

AU - Mendieta, Danelia

AU - la Cruz-Aguilera, Dora Luz De

AU - Barrera-Villalpando, Maria Isabel

AU - Becerril-Villanueva, Enrique

AU - Arreola, Rodrigo

AU - Hernández-Ferreira, Erick

AU - Pérez-Tapia, Sonia Mayra

AU - Pérez-Sánchez, Gilberto

AU - Garcés-Alvarez, María Eugenia

AU - Aguirre-Cruz, Lucinda

AU - Velasco-Velázquez, Marco Antonio

AU - Pavón, Lenin

PY - 2016/1/15

Y1 - 2016/1/15

N2 - Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.

AB - Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.

KW - FIQ

KW - Fibromyalgia

KW - IL-6

KW - IL-8

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=84955156152&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2015.11.011

DO - 10.1016/j.jneuroim.2015.11.011

M3 - Artículo

SN - 0165-5728

VL - 290

SP - 22

EP - 25

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients

Abstract

Keywords

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