TY - JOUR
T1 - Hypocaloric diet and regular moderate aerobic exercise is an effective strategy to reduce anthropometric parameters and oxidative stress in obese patients
AU - Gutierrez-Lopez, Liliana
AU - Garcia-Sanchez, Jose Ruben
AU - Rincon-Viquez, Maria De Jesus
AU - Lara-Padilla, Eleazar
AU - Sierra-Vargas, Martha P.
AU - Olivares-Corichi, Ivonne M.
PY - 2012/3
Y1 - 2012/3
N2 - Background: Studies show that diet and exercise are important in the treatment of obesity. The aim of this study was to determine whether additional regular moderate aerobic exercise during a treatment with hypocaloric diet has a beneficial effect on oxidative stress and molecular damage in the obese patient. Methods: Oxidative stress of 16 normal-weight (NW) and 32 obese 1 (O1) subjects (BMI 30-34.9 kg/m 2) were established by biomarkers of oxidative stress in plasma. Recombinant human insulin was incubated with blood from NW or O1 subjects, and the molecular damage to the hormone was analyzed. Two groups of treatment, hypocaloric diet (HD) and hypocaloric diet plus regular moderate aerobic exercise (HDMAE), were formed, and their effects in obese subjects were analyzed. Results: The data showed the presence of oxidative stress in O1 subjects. Molecular damage and polymerization of insulin was observed more frequently in the blood from O1 subjects. The treatment of O1 subjects with HD decreased the anthropometric parameters as well as oxidative stress and molecular damage, which was more effectively prevented by the treatment with HDMAE. Conclusion: HD and HDMAE treatments decreased anthropometric parameters, oxidative stress, and molecular damage in O1 subjects.
AB - Background: Studies show that diet and exercise are important in the treatment of obesity. The aim of this study was to determine whether additional regular moderate aerobic exercise during a treatment with hypocaloric diet has a beneficial effect on oxidative stress and molecular damage in the obese patient. Methods: Oxidative stress of 16 normal-weight (NW) and 32 obese 1 (O1) subjects (BMI 30-34.9 kg/m 2) were established by biomarkers of oxidative stress in plasma. Recombinant human insulin was incubated with blood from NW or O1 subjects, and the molecular damage to the hormone was analyzed. Two groups of treatment, hypocaloric diet (HD) and hypocaloric diet plus regular moderate aerobic exercise (HDMAE), were formed, and their effects in obese subjects were analyzed. Results: The data showed the presence of oxidative stress in O1 subjects. Molecular damage and polymerization of insulin was observed more frequently in the blood from O1 subjects. The treatment of O1 subjects with HD decreased the anthropometric parameters as well as oxidative stress and molecular damage, which was more effectively prevented by the treatment with HDMAE. Conclusion: HD and HDMAE treatments decreased anthropometric parameters, oxidative stress, and molecular damage in O1 subjects.
KW - Diet
KW - Exercise
KW - Free radicals
KW - Insulin resistance
KW - Obesity
KW - Oxidative stress
KW - Reactive oxygen species
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=84858841207&partnerID=8YFLogxK
U2 - 10.1159/000336526
DO - 10.1159/000336526
M3 - Artículo
SN - 1662-4025
VL - 5
SP - 12
EP - 22
JO - Obesity Facts
JF - Obesity Facts
IS - 1
ER -