Hydrogen bonding in pharmacy: Oxalic acid derivatives as a case of study

Herein, an overview of the work that our group has developed using oxalamate/oxalamide derivatives is presented. First, we deal with general aspects of oxalic acid in the context of pharmacy, followed by a brief description of structural features of these molecules supported on multinuclear NMR spectroscopy, IR, voltamperometric studies and x-ray diffraction. Results indicate the robustness, reliability and versatility of these systems both in the solid and solution, characteristics that make them suitable for further tests as co-crystallizers of pharmaceutical compounds and molecular gelling agents.