TY - JOUR
T1 - HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population
AU - Aguilar-Medina, Maribel
AU - Escamilla-Tilch, Monica
AU - Fr�as-Castro, Luis Octavio
AU - Romero-Quintana, Geovanni
AU - Estrada-Garc�a, Iris
AU - Estrada-Parra, Sergio
AU - Granados, Julio
AU - Arambula Meraz, Eliakym
AU - S�nchez-Schmitz, Guzman
AU - Khader, Shabaana Abdul
AU - Rangel-Moreno, Javier
AU - Ramos-Pay�n, Rosal�o
N1 - Publisher Copyright:
� 2016 John Wiley & Sons Ltd/University College London
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control�subjects (n = 117) from the region with the highest incidence for the disease in M�xico. The odds of developing leprosy and lepromatous subtype were 2.12- and 2.74-fold higher in carriers of HLA-A*28, and 2.48- and 4.14-fold higher for leprosy and dimorphic subtype in carriers of DQB1*06. Interestingly, DQB1*07 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA-A*28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB1*06 to leprosy and the dimorphic subtype, while DQB1*07 might be a resistance marker in this Mestizo population.
AB - Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control�subjects (n = 117) from the region with the highest incidence for the disease in M�xico. The odds of developing leprosy and lepromatous subtype were 2.12- and 2.74-fold higher in carriers of HLA-A*28, and 2.48- and 4.14-fold higher for leprosy and dimorphic subtype in carriers of DQB1*06. Interestingly, DQB1*07 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA-A*28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB1*06 to leprosy and the dimorphic subtype, while DQB1*07 might be a resistance marker in this Mestizo population.
KW - HLA
KW - Leprosy
KW - Mexicans
KW - susceptibility
UR - http://www.scopus.com/inward/record.url?scp=85007407824&partnerID=8YFLogxK
U2 - 10.1111/ahg.12183
DO - 10.1111/ahg.12183
M3 - Artículo
C2 - 28025823
SN - 0003-4800
VL - 81
SP - 35
EP - 40
JO - Annals of Human Genetics
JF - Annals of Human Genetics
IS - 1
ER -