Abstract
With the aim of evaluating the pharmacophore potential of the side chain of α-asarone (1) regarding its high hypolipidemic activity, the series of derivatives 7a-7e, and 11-13 were evaluated pharmacologically. For the hydrocarbon compounds 7a-7e, with a variable-size side chain, significant decreases in serum cholesterol, LDL-cholesterol, and triglyceride levels and significant increases in HDL-cholesterol levels were observed in mice. The small-size side-chain derivatives were even more active than 1 in reducing cholesterol. The results suggested that the length and saturated character of the side chain seem to be a key feature in improving hypolipidemic activity of α-asarone (1) analogs.
| Original language | English |
|---|---|
| Pages (from-to) | 587-595 |
| Number of pages | 9 |
| Journal | Medicinal Chemistry Research |
| Volume | 10 |
| Issue number | 9 |
| State | Published - 2001 |