TY - JOUR
T1 - Genome sequence and attenuating mutations in Nile virus isolate from Mexico
AU - Beasley, David W.C.
AU - Davis, C. Todd
AU - Estrada-Franco, Jose
AU - Navarro-Lopes, Roberto
AU - Campomanes-Cortes, Arturo
AU - Tesh, Robert B.
AU - Weaver, Scott C.
AU - Barrett, Alan D.T.
PY - 2004/12
Y1 - 2004/12
N2 - The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
AB - The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
UR - http://www.scopus.com/inward/record.url?scp=9744232885&partnerID=8YFLogxK
U2 - 10.3201/eid1012.040647
DO - 10.3201/eid1012.040647
M3 - Artículo
SN - 1080-6040
VL - 10
SP - 2221
EP - 2224
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 12
ER -