TY - JOUR
T1 - Flumazenil blocks the anxiolytic action of allopregnanolone
AU - Fernández-Guasti, Alonso
AU - Picazo, Ofir
N1 - Funding Information:
The authors wish to thank Mr. Facundo Moreno for technical assistance and Mr. Victor Flores for care of the animals. The present study was partially supported by a grant to A.F.-G. (grant No. 1709-M9209) from the 'Consejo Nacional de Ciencia y Tecnologia (CON-ACyT)'. O.P. received a doctorate fellowship from CONACyT.
PY - 1995/7/25
Y1 - 1995/7/25
N2 - In the burying behaviour test allopregnanolone (0.5 mg/rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg/kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced by allopregnanolone. No scheme modified the ambulatory behaviour, thus suggesting that the effect of these treatments was selective on experimental anxiety. These results indicate that the anxiolytic actions of neurosteroids are most likely mediated via the stimulation of GABAA receptors. Data are discussed on the basis of such relationships.
AB - In the burying behaviour test allopregnanolone (0.5 mg/rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg/kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced by allopregnanolone. No scheme modified the ambulatory behaviour, thus suggesting that the effect of these treatments was selective on experimental anxiety. These results indicate that the anxiolytic actions of neurosteroids are most likely mediated via the stimulation of GABAA receptors. Data are discussed on the basis of such relationships.
KW - Allopregnanolone
KW - Anxiety
KW - Burying behavior
KW - Flumazenil
UR - http://www.scopus.com/inward/record.url?scp=0029122845&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(95)00311-8
DO - 10.1016/0014-2999(95)00311-8
M3 - Artículo
SN - 0014-2999
VL - 281
SP - 113
EP - 115
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -