TY - JOUR
T1 - Farmacogenómica como herramienta fundamental para la medicina personalizada
T2 - Aplicaciones en la práctica clínica
AU - Quiñones, Luis
AU - Roco, Ángela
AU - Cayún, Juan P.
AU - Escalante, Paula
AU - Miranda, Carla
AU - Varela, Nelson
AU - Meneses, Francisca
AU - Gallegos, Bastián
AU - Zaruma-Torres, Fausto
AU - Lares-Asseff, Ismael
N1 - Publisher Copyright:
© 2017, Sociedad Medica de Santiago. All rights reserved.
PY - 2017/4
Y1 - 2017/4
N2 - Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
AB - Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
KW - Genetic
KW - Pharmacogenetics
KW - Pharmacogenomic variants
KW - Pharmacokinetics
KW - Polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=85025626896&partnerID=8YFLogxK
U2 - 10.4067/S0034-98872017000400009
DO - 10.4067/S0034-98872017000400009
M3 - Artículo
C2 - 28748996
SN - 0034-9887
VL - 145
SP - 483
EP - 500
JO - Revista Medica de Chile
JF - Revista Medica de Chile
IS - 4
ER -