Factor de necrosis tumoral-α e interleucina-1 β en los compartimentos intravascular materno, fetal y retroplacentario en parto a termino y pretermino

Neonato preterm birth (before 37 pregnancy weeks) account more than 80% perinatal deaths not attribuible to congenital malformations. Preterm and term labor full mechanisms are unknow at present. Proinflammatory citokynes direct participation have been involved in the phenomena by several experimental evidence. The study's aim was to determine TNF-α and IL-1β concentration at maternal, fetal and fetal-maternal vascular compartments in women with term and preterm delivery and in women at term childbirth without labor. TNF-α and IL-1β concentration were determinated by comercial immunoassay. TNF-α concentration showed a tendency to be in more proportion at fetal and fetal-maternal compartments in preterm and term childbirth groups versus TNF-α concentration in term group without labor at same places. IL-1β concentration showed same tendency of increase than TNF-α in preterm and term childbirth groups, but alone at fetal-maternal compartment. Statistical difference were not documented at any compartment or group compared. Data allow to identify fetal-maternal compartments as target places where TNF-α and IL-β were synthesized. Gradient concentration synthesis of citokynes allows to intend fetus as TNF-α initial producer.