Facile synthesis of aminoalcohols by ring opening of epoxides under solvent free conditions

Gloria Huerta; Guadalupe Contreras-Ordoñez; C. Alvarez-Toledano; Víctor Santes; Elizabeth Gómez; Rubén A. Toscano

doi:10.1081/SCC-120039493

Facile synthesis of aminoalcohols by ring opening of epoxides under solvent free conditions

Gloria Huerta, Guadalupe Contreras-Ordoñez, C. Alvarez-Toledano, Víctor Santes, Elizabeth Gómez, Rubén A. Toscano

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The convenient cleavage of symmetrical and unsymmetrical epoxides with either aromatic or aliphatic amine under solvent free conditions is reported. The reactions were carried out in a sealed ampoule at 90°C to give regioselectively the corresponding β-amino alcohol in one pot in high yields.

Original language	English
Pages (from-to)	2393-2406
Number of pages	14
Journal	Synthetic Communications
Volume	34
Issue number	13
DOIs	https://doi.org/10.1081/SCC-120039493
State	Published - 2004
Externally published	Yes

Keywords

Aromatic amines
Epoxide
Facile synthesis
Regioisomers
β-Aminoalcohols

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10.1081/SCC-120039493

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title = "Facile synthesis of aminoalcohols by ring opening of epoxides under solvent free conditions",

abstract = "The convenient cleavage of symmetrical and unsymmetrical epoxides with either aromatic or aliphatic amine under solvent free conditions is reported. The reactions were carried out in a sealed ampoule at 90°C to give regioselectively the corresponding β-amino alcohol in one pot in high yields.",

keywords = "Aromatic amines, Epoxide, Facile synthesis, Regioisomers, β-Aminoalcohols",

author = "Gloria Huerta and Guadalupe Contreras-Ordo{\~n}ez and C. Alvarez-Toledano and V{\'i}ctor Santes and Elizabeth G{\'o}mez and Toscano, {Rub{\'e}n A.}",

note = "Funding Information: Financial support from DGAPA (IN 207103) is grateful acknowledged. Authors thank Francisco Javier P{\'e}rez, Luis Velasco, Myrian Adaya and Roc{\'i}o Pati{\~n}o for technical support.",

year = "2004",

doi = "10.1081/SCC-120039493",

language = "Ingl{\'e}s",

volume = "34",

pages = "2393--2406",

journal = "Synthetic Communications",

issn = "0039-7911",

number = "13",

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TY - JOUR

T1 - Facile synthesis of aminoalcohols by ring opening of epoxides under solvent free conditions

AU - Huerta, Gloria

AU - Contreras-Ordoñez, Guadalupe

AU - Alvarez-Toledano, C.

AU - Santes, Víctor

AU - Gómez, Elizabeth

AU - Toscano, Rubén A.

N1 - Funding Information: Financial support from DGAPA (IN 207103) is grateful acknowledged. Authors thank Francisco Javier Pérez, Luis Velasco, Myrian Adaya and Rocío Patiño for technical support.

PY - 2004

Y1 - 2004

N2 - The convenient cleavage of symmetrical and unsymmetrical epoxides with either aromatic or aliphatic amine under solvent free conditions is reported. The reactions were carried out in a sealed ampoule at 90°C to give regioselectively the corresponding β-amino alcohol in one pot in high yields.

AB - The convenient cleavage of symmetrical and unsymmetrical epoxides with either aromatic or aliphatic amine under solvent free conditions is reported. The reactions were carried out in a sealed ampoule at 90°C to give regioselectively the corresponding β-amino alcohol in one pot in high yields.

KW - Aromatic amines

KW - Epoxide

KW - Facile synthesis

KW - Regioisomers

KW - β-Aminoalcohols

UR - http://www.scopus.com/inward/record.url?scp=3543104417&partnerID=8YFLogxK

U2 - 10.1081/SCC-120039493

DO - 10.1081/SCC-120039493

M3 - Artículo

SN - 0039-7911

VL - 34

SP - 2393

EP - 2406

JO - Synthetic Communications

JF - Synthetic Communications

IS - 13

ER -

Facile synthesis of aminoalcohols by ring opening of epoxides under solvent free conditions

Abstract

Keywords

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