TY - JOUR
T1 - Extraction of Galphimines from Galphimia glauca with Supercritical Carbon Dioxide
AU - Verónico Sánchez, Francisco Javier
AU - Solis, Octavio Elizalde
AU - Zamilpa, Alejandro
AU - Morales, Ricardo García
AU - Dolores Pérez García, Ma
AU - Jiménez Ferrer, Jesús E.
AU - Tortoriello, Jaime
N1 - Publisher Copyright:
© 2020 by the authors.
PY - 2020/1/22
Y1 - 2020/1/22
N2 - The anti-depressive and anxiolytic effect of galphimine B (isolated from Galphimia glauca) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work, supercritical extractions of galphimines from Galphimia glauca were performed in the presence of carbon dioxide. Pressure, temperature, particle diameter, and flow rate effects were examined to explore the conditions with the highest yield and the concentration profile of galphimines in the studied interval. The identification of the nor-seco triterpenoids and galphimine B and E was carried out by HPLC analyses. The mathematical modeling of the extraction curves was attained by the approaches proposed by Sovová and Papamichail et al. According to results, the highest yield 2.22% was obtained at 323.15 K, 326 µm, 3 L/min, and 33.75 MPa. Meanwhile, the content of galphimine B in the extract was, on average, 19.5 mg·g−1.
AB - The anti-depressive and anxiolytic effect of galphimine B (isolated from Galphimia glauca) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work, supercritical extractions of galphimines from Galphimia glauca were performed in the presence of carbon dioxide. Pressure, temperature, particle diameter, and flow rate effects were examined to explore the conditions with the highest yield and the concentration profile of galphimines in the studied interval. The identification of the nor-seco triterpenoids and galphimine B and E was carried out by HPLC analyses. The mathematical modeling of the extraction curves was attained by the approaches proposed by Sovová and Papamichail et al. According to results, the highest yield 2.22% was obtained at 323.15 K, 326 µm, 3 L/min, and 33.75 MPa. Meanwhile, the content of galphimine B in the extract was, on average, 19.5 mg·g−1.
KW - Carbon dioxide
KW - Galphimia glauca
KW - Galphimine B
KW - Kinetic modeling
KW - Supercritical extraction
KW - árnica roja
UR - http://www.scopus.com/inward/record.url?scp=85078279158&partnerID=8YFLogxK
U2 - 10.3390/molecules25030477
DO - 10.3390/molecules25030477
M3 - Artículo
C2 - 31979179
AN - SCOPUS:85078279158
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 3
M1 - 477
ER -