Expression profiles of GPR21, GPR39, GPR135, and GPR153 orphan receptors in different cancers

Juan René Gutiérrez-Ruiz, Santiago Villafaña, Armando Ruiz-Hernández, Diocelina Viruette-Pontigo, Celestina Menchaca-Cervantes, Karla Aidee Aguayo-Cerón, Fengyang Huang, Enrique Hong, Rodrigo Romero-Nava

Research output: Contribution to journalArticlepeer-review


Orphan receptors have unknown endogenous ligands, are expressed in different tissues, and participate in various diseases such as diabetes, hypertension and cancer. We studied the expression profiles of GPR21, GPR39, GPR135 and GPR153 orphan receptors in several tumour tissues. Cervical, breast, skin, prostate, and astrocytoma tissues were analysed for orphan receptor gene expression using Real time PCR analysis. GPR39 is over-expressed in cervical and prostate cancer tissues, and GPR21 and GPR135 receptors are significantly decreased in cervical, breast, skin, prostate, and astrocytoma tissues, when compared with healthy human fibroblasts. In conclusion, GPR21 and GPR135 receptor gene expression is reduced in cancerous tissues. GPR39 may have a role in the development and evolution of cervical and prostate cancer. These data suggest these receptors may be alternative molecules for new diagnostic approaches, and the design of novel therapeutics against oncological pathologies.

Original languageEnglish
Pages (from-to)123-136
Number of pages14
JournalNucleosides, Nucleotides and Nucleic Acids
Issue number2
StatePublished - 2022


  • cancer
  • GPR135
  • GPR153
  • GPR21
  • GPR39
  • Orphan receptors


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