TY - JOUR
T1 - Expression profiles of GPR21, GPR39, GPR135, and GPR153 orphan receptors in different cancers
AU - Gutiérrez-Ruiz, Juan René
AU - Villafaña, Santiago
AU - Ruiz-Hernández, Armando
AU - Viruette-Pontigo, Diocelina
AU - Menchaca-Cervantes, Celestina
AU - Aguayo-Cerón, Karla Aidee
AU - Huang, Fengyang
AU - Hong, Enrique
AU - Romero-Nava, Rodrigo
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Orphan receptors have unknown endogenous ligands, are expressed in different tissues, and participate in various diseases such as diabetes, hypertension and cancer. We studied the expression profiles of GPR21, GPR39, GPR135 and GPR153 orphan receptors in several tumour tissues. Cervical, breast, skin, prostate, and astrocytoma tissues were analysed for orphan receptor gene expression using Real time PCR analysis. GPR39 is over-expressed in cervical and prostate cancer tissues, and GPR21 and GPR135 receptors are significantly decreased in cervical, breast, skin, prostate, and astrocytoma tissues, when compared with healthy human fibroblasts. In conclusion, GPR21 and GPR135 receptor gene expression is reduced in cancerous tissues. GPR39 may have a role in the development and evolution of cervical and prostate cancer. These data suggest these receptors may be alternative molecules for new diagnostic approaches, and the design of novel therapeutics against oncological pathologies.
AB - Orphan receptors have unknown endogenous ligands, are expressed in different tissues, and participate in various diseases such as diabetes, hypertension and cancer. We studied the expression profiles of GPR21, GPR39, GPR135 and GPR153 orphan receptors in several tumour tissues. Cervical, breast, skin, prostate, and astrocytoma tissues were analysed for orphan receptor gene expression using Real time PCR analysis. GPR39 is over-expressed in cervical and prostate cancer tissues, and GPR21 and GPR135 receptors are significantly decreased in cervical, breast, skin, prostate, and astrocytoma tissues, when compared with healthy human fibroblasts. In conclusion, GPR21 and GPR135 receptor gene expression is reduced in cancerous tissues. GPR39 may have a role in the development and evolution of cervical and prostate cancer. These data suggest these receptors may be alternative molecules for new diagnostic approaches, and the design of novel therapeutics against oncological pathologies.
KW - GPR135
KW - GPR153
KW - GPR21
KW - GPR39
KW - Orphan receptors
KW - cancer
UR - http://www.scopus.com/inward/record.url?scp=85122883163&partnerID=8YFLogxK
U2 - 10.1080/15257770.2021.2002892
DO - 10.1080/15257770.2021.2002892
M3 - Artículo
C2 - 35021931
AN - SCOPUS:85122883163
SN - 1525-7770
VL - 41
SP - 123
EP - 136
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 2
ER -