TY - JOUR
T1 - Expression of the 5-HT receptors in rat brain during memory consolidation
AU - Meneses, A.
AU - Manuel-Apolinar, L.
AU - Rocha, L.
AU - Castillo, E.
AU - Castillo, C.
N1 - Funding Information:
This work was partially supported by CONACYT Grant 39534-M. L.M.A. was supported by the CONACYT scholarship No. 165460. The authors thank to Sofia Meneses-Goytia and Rafael Villalobos for revised language, and Roberto Gonzalez for his expertise assistance. Finally, Magdalena Briones, Leticia Neri and Hector Vázquez deserve our thankful for their technical support.
PY - 2004/7/9
Y1 - 2004/7/9
N2 - Serotonin (5-hydroxytryptamine, 5-HT) system displays more than 14 receptors subtypes on brain areas involved in learning and memory processes, and pharmacological manipulation of specific receptors selectively affects memory formation. In order to begin the search of 5-HT receptors expression during memory formation, in this work, we aimed to determine, by autoradiography (using [3H] 5-HT as ligand, 2 nM, specific activity 123 Ci/mmol), 5-HT receptors (5-HTR) expression in passive (untrained) and autoshaping trained (3 sessions) adult (3 months) and old (9 months) male rats. Thus, trained adult rats had better retention than old animals. Raphe nuclei of adult and old trained rats expressed less receptors on medial and dorsal, respectively. Hippocampal CA1 area and dentate gyrus of adult trained rats expressed less 5-HTR, while dentate gyrus of old increased them. Basomedial amygdaloid nucleus in old trained rats expressed more 5-HTR; while in the basolateral amygdaloid nucleus they were augmented in both groups. Training decreased or did not change 5-HTR in caudate-putamen of adult or old animals. The above profile of 5-HTR expression is consistent with previous reports, and suggests that memory formation and aging modulates 5-HTR expression in brain areas relevant to memory systems.
AB - Serotonin (5-hydroxytryptamine, 5-HT) system displays more than 14 receptors subtypes on brain areas involved in learning and memory processes, and pharmacological manipulation of specific receptors selectively affects memory formation. In order to begin the search of 5-HT receptors expression during memory formation, in this work, we aimed to determine, by autoradiography (using [3H] 5-HT as ligand, 2 nM, specific activity 123 Ci/mmol), 5-HT receptors (5-HTR) expression in passive (untrained) and autoshaping trained (3 sessions) adult (3 months) and old (9 months) male rats. Thus, trained adult rats had better retention than old animals. Raphe nuclei of adult and old trained rats expressed less receptors on medial and dorsal, respectively. Hippocampal CA1 area and dentate gyrus of adult trained rats expressed less 5-HTR, while dentate gyrus of old increased them. Basomedial amygdaloid nucleus in old trained rats expressed more 5-HTR; while in the basolateral amygdaloid nucleus they were augmented in both groups. Training decreased or did not change 5-HTR in caudate-putamen of adult or old animals. The above profile of 5-HTR expression is consistent with previous reports, and suggests that memory formation and aging modulates 5-HTR expression in brain areas relevant to memory systems.
KW - 5-HT
KW - Autoshaping
KW - Learning
KW - Memory
KW - Rat
KW - Receptors
KW - [H] 5-HT
UR - http://www.scopus.com/inward/record.url?scp=2942527628&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2003.10.037
DO - 10.1016/j.bbr.2003.10.037
M3 - Artículo
C2 - 15196811
SN - 0166-4328
VL - 152
SP - 425
EP - 436
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -