TY - JOUR
T1 - Expression of KLF4 is a predictive marker for survival in pediatric Burkitt lymphoma
AU - Valencia-Hipólito, Alberto
AU - Hernández-Atenógenes, Miriam
AU - Vega, Gabriel G.
AU - Maldonado-Valenzuela, Altagracia
AU - Ramon, Guillermo
AU - Mayani, Héctor
AU - Peña Alonso, Yolanda
AU - Martinez-Maza, Otoniel
AU - Méndez-Tenorio, Alfonso
AU - Huerta-Yepez, Sara
AU - Bonavida, Benjamin
AU - Vega, Mario I.
N1 - Funding Information:
This study was supported in part by academic support from SEP-CONACYT, Mexico (MIV CB-2011-01, 169368) and Grant FIS/IMSS/PROT/G10/837 from the IMSS (M.I.V.), UC MEXUS-CONACYT (M.I.V. and O.M.-M., Collaborative Research Grants CN-11-554), CONACYT (A.H.-V., M.H.-A., G.G.V.), Jonsson Comprehensive Cancer Center (M.I.V.), UCLA AIDS Institute (M.I.V.) and a Fogarty International Center Fellowship (D43 TW00013-14) (M.I.V. and S.H.-Y.). This study was also supported by various donors (B.B.) and by the Johnson Comprehensive Cancer Center at UCLA (B.B.).
PY - 2014/8
Y1 - 2014/8
N2 - Krüppel-like factor 4 (KLF4) is expressed in a variety of tissues with diverse physiological functions and activities. KLF4 can also function as a tumor suppressor or an oncogene, depending on the cellular context. Its role in hematological malignancies is controversial. This study examined the expression levels of KLF4 by immunohistochemistry in 73 pediatric non-Hodgkin lymphomas (NHLs) in a tissue microarray and also on several B-NHL cell lines. Elevated levels of KLF4 expression were detected in 66% of lymphoma cases and were more frequent in the Burkitt lymphoma (p = 0.05) subtype. There was a significant predictive power for outcome with low KLF4 expression, predicting a favorable overall survival compared to high levels. Multivariate analyses confirmed the association of KLF4 expression with unfavorable overall survival (p < 0.005). These findings were consistent with analyses in existing NHL microarray datasets. The present findings revealed that KLF4 is overexpressed in Burkitt pediatric lymphoma and is a potential biomarker for inferior overall survival.
AB - Krüppel-like factor 4 (KLF4) is expressed in a variety of tissues with diverse physiological functions and activities. KLF4 can also function as a tumor suppressor or an oncogene, depending on the cellular context. Its role in hematological malignancies is controversial. This study examined the expression levels of KLF4 by immunohistochemistry in 73 pediatric non-Hodgkin lymphomas (NHLs) in a tissue microarray and also on several B-NHL cell lines. Elevated levels of KLF4 expression were detected in 66% of lymphoma cases and were more frequent in the Burkitt lymphoma (p = 0.05) subtype. There was a significant predictive power for outcome with low KLF4 expression, predicting a favorable overall survival compared to high levels. Multivariate analyses confirmed the association of KLF4 expression with unfavorable overall survival (p < 0.005). These findings were consistent with analyses in existing NHL microarray datasets. The present findings revealed that KLF4 is overexpressed in Burkitt pediatric lymphoma and is a potential biomarker for inferior overall survival.
KW - Burkitt
KW - EFS
KW - KLF4
KW - OS
KW - Pediatric Burkitt lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84904886249&partnerID=8YFLogxK
U2 - 10.3109/10428194.2013.848437
DO - 10.3109/10428194.2013.848437
M3 - Artículo
C2 - 24067139
SN - 1042-8194
VL - 55
SP - 1806
EP - 1814
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -