Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy

L. Hernández-Quintanar, S. Stolik, J. M. De La Rosa

Research output: Contribution to conferencePaper

Abstract

Photodynamic therapy involves the administration of a photosensitizer drug followed by a local illumination with light of specific wavelength. In the presence of oxygen molecules, the light illumination of photosensitizer can activate the production of reactive oxygen species which produce the death of malignant cells. Light dose is an important factor for reach an effective therapy. In this work it is presented an irradiation system which allows the application of radiation at 630 nm for 5-AminoLevulinic Acid superficial Photodynamic Therapy using as a light source, a light emitting diode and an automatic control of output optical power using the results of a model of distribution of radiation in depth for different optical properties. The system was tested in tissue phantoms which allow a more controlled environment than test in vivo or in vitro. © 2012 IEEE.
Original languageAmerican English
Pages45-49
Number of pages40
DOIs
StatePublished - 24 May 2012
EventCONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing -
Duration: 24 May 2012 → …

Conference

ConferenceCONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing
Period24/05/12 → …

Fingerprint

Photodynamic therapy
Dosimetry
Photosensitizing Agents
Photosensitizers
Tissue
Lighting
Radiation
Aminolevulinic Acid
Oxygen
Light emitting diodes
Light sources
Reactive Oxygen Species
Optical properties
Cells
Irradiation
Wavelength
Molecules
Acids
Pharmaceutical Preparations

Cite this

Hernández-Quintanar, L., Stolik, S., & De La Rosa, J. M. (2012). Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy. 45-49. Paper presented at CONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing, . https://doi.org/10.1109/CONIELECOMP.2012.6189879
Hernández-Quintanar, L. ; Stolik, S. ; De La Rosa, J. M. / Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy. Paper presented at CONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing, .40 p.
@conference{1880ad6f3ce7457bba9ef506fd30ccd5,
title = "Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy",
abstract = "Photodynamic therapy involves the administration of a photosensitizer drug followed by a local illumination with light of specific wavelength. In the presence of oxygen molecules, the light illumination of photosensitizer can activate the production of reactive oxygen species which produce the death of malignant cells. Light dose is an important factor for reach an effective therapy. In this work it is presented an irradiation system which allows the application of radiation at 630 nm for 5-AminoLevulinic Acid superficial Photodynamic Therapy using as a light source, a light emitting diode and an automatic control of output optical power using the results of a model of distribution of radiation in depth for different optical properties. The system was tested in tissue phantoms which allow a more controlled environment than test in vivo or in vitro. {\circledC} 2012 IEEE.",
author = "L. Hern{\'a}ndez-Quintanar and S. Stolik and {De La Rosa}, {J. M.}",
year = "2012",
month = "5",
day = "24",
doi = "10.1109/CONIELECOMP.2012.6189879",
language = "American English",
pages = "45--49",
note = "CONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing ; Conference date: 24-05-2012",

}

Hernández-Quintanar, L, Stolik, S & De La Rosa, JM 2012, 'Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy', Paper presented at CONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing, 24/05/12 pp. 45-49. https://doi.org/10.1109/CONIELECOMP.2012.6189879

Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy. / Hernández-Quintanar, L.; Stolik, S.; De La Rosa, J. M.

2012. 45-49 Paper presented at CONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing, .

Research output: Contribution to conferencePaper

TY - CONF

T1 - Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy

AU - Hernández-Quintanar, L.

AU - Stolik, S.

AU - De La Rosa, J. M.

PY - 2012/5/24

Y1 - 2012/5/24

N2 - Photodynamic therapy involves the administration of a photosensitizer drug followed by a local illumination with light of specific wavelength. In the presence of oxygen molecules, the light illumination of photosensitizer can activate the production of reactive oxygen species which produce the death of malignant cells. Light dose is an important factor for reach an effective therapy. In this work it is presented an irradiation system which allows the application of radiation at 630 nm for 5-AminoLevulinic Acid superficial Photodynamic Therapy using as a light source, a light emitting diode and an automatic control of output optical power using the results of a model of distribution of radiation in depth for different optical properties. The system was tested in tissue phantoms which allow a more controlled environment than test in vivo or in vitro. © 2012 IEEE.

AB - Photodynamic therapy involves the administration of a photosensitizer drug followed by a local illumination with light of specific wavelength. In the presence of oxygen molecules, the light illumination of photosensitizer can activate the production of reactive oxygen species which produce the death of malignant cells. Light dose is an important factor for reach an effective therapy. In this work it is presented an irradiation system which allows the application of radiation at 630 nm for 5-AminoLevulinic Acid superficial Photodynamic Therapy using as a light source, a light emitting diode and an automatic control of output optical power using the results of a model of distribution of radiation in depth for different optical properties. The system was tested in tissue phantoms which allow a more controlled environment than test in vivo or in vitro. © 2012 IEEE.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862081025&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84862081025&origin=inward

U2 - 10.1109/CONIELECOMP.2012.6189879

DO - 10.1109/CONIELECOMP.2012.6189879

M3 - Paper

SP - 45

EP - 49

ER -

Hernández-Quintanar L, Stolik S, De La Rosa JM. Experimental tests in tissue phantoms of a photoirradiation system with optical dosimetry for photodynamic therapy. 2012. Paper presented at CONIELECOMP 2012 - 22nd International Conference on Electronics Communications and Computing, . https://doi.org/10.1109/CONIELECOMP.2012.6189879